Comparison of Cardiac Computed Tomography for the Detection of Coronary Artery Disease With Nuclear Stress Test

Providence VA Medical Center

Status: Completed

Conditions: Coronary Arteriosclerosis

Study type: Observational

Funder types: Other U.S. Federal agency

Identifiers

NCT00352937

1124528

Details and patient eligibility

About

To compare the efficacy of 16-row multi-detector CT (MDCT) with standard myocardial perfusion imaging in detecting coronary artery disease (CAD) in patients without a previously established diagnosis of CAD.

Full description

Nuclear stress testing is currently the established non-invasive modality in detecting flow-obstructing coronary artery disease (CAD).

Recently, multi-detector CT (MDCT) has emerged as a new modality that offers a non-invasive means to directly visualize coronary anatomy and any CAD. Studies have shown that MDCT has excellent sensitivity and a high negative predictive value in detecting significant CAD.

The purpose of this study is to compare MDCT with nuclear stress testing for detecting CAD in previously undiagnosed patients.

Enrollment: 98 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Referred for a clinical indicated stress SPECT MPI
• Adequate IV access in both arms

Exclusion criteria

• History of coronary angioplasty or stent placement
• History of coronary bypass surgery
• Angiographic history of flow-limiting CAD
• Documented history of elevated cardiac markers
• Documented history of injury or infarct on ECG
• Absence of sinus rhythm
• Current history of renal insufficiency
• Known allergy to contrast dye
• Pregnant