Comparison of Carotenoid Bioavailability From Fresh Papaya, Tomato and Carrot

The Ohio State University logo

The Ohio State University

Status

Completed

Conditions

Focus of Study: Carotenoid Absorption

Treatments

Other: Carrot
Other: Tomato
Other: Papaya

Study type

Interventional

Funder types

Other

Identifiers

NCT01748916
2011H0336

Details and patient eligibility

About

The goal of this study is to determine if papaya fruits are an exceptionally good food source for carotenoids in humans, particularly when compared more common carotenoid sources like carrots and tomatoes. This objective will be accomplished by quantitation of the immediate post-prandial plasma concentrations of parent carotenoids and vitamin A metabolites from subjects who consumed a meal containing fresh papaya, tomato, and carrot.

Full description

The main purpose of this study is comparing bioavailability of papaya carotenoids versus carrot and tomato carotenoids. Previously, vitamin A deposition in rat livers was studied, showing that carotenoid bioavailability from papaya is higher than from spinach, parsley and carrots. Detailed knowledge about human carotenoid absorption and conversion from papaya fruit compared to other food sources is still lacking.

Enrollment

16 patients

Sex

All

Ages

18 to 70 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • healthy individuals

Exclusion criteria

  • lactating, pregnant, or planned to be pregnant
  • smokers/those who use tobacco products
  • metabolic or malabsorption disorders
  • had a history of cancer
  • history of liver insufficiency or other gastro-intestinal diseases
  • allergy to papaya, carrots or tomatoes
  • obesity

Trial design

Primary purpose

Basic Science

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

None (Open label)

16 participants in 6 patient groups

Papaya-Carrot-Tomato
Experimental group
Description:
Test meals were consumed in the following order: 1. Papaya 2. Carrot 3. Tomato.
Treatment:
Other: Papaya
Other: Tomato
Other: Carrot
Papaya-Tomato-Carrot
Experimental group
Description:
Test meals were consumed in the following order: 1. Papaya 2. Tomato 3. Carrot
Treatment:
Other: Papaya
Other: Tomato
Other: Carrot
Tomato-Papaya-Carrot
Experimental group
Description:
Test meals were consumed in the following order: 1. Tomato 2. Papaya 3. Carrot
Treatment:
Other: Papaya
Other: Tomato
Other: Carrot
Tomato-Carrot-Papaya
Experimental group
Description:
Test meals were consumed in the following order: 1. Tomato 2. Carrot 3. Papaya
Treatment:
Other: Papaya
Other: Tomato
Other: Carrot
Carrot-Papaya-Tomato
Experimental group
Description:
Test meals were consumed in the following order: 1. Carrot 2. Papaya 3. Tomato
Treatment:
Other: Papaya
Other: Tomato
Other: Carrot
Carrot-Tomato-Papaya
Experimental group
Description:
Test meals were consumed in the following order: 1. Carrot 2. Tomato 3. Papaya
Treatment:
Other: Papaya
Other: Tomato
Other: Carrot

Trial contacts and locations

2

Loading...

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location
© Copyright 2024 Veeva Systems