Comparison of Carotenoid Bioavailability From Fresh Papaya, Tomato and Carrot

The Ohio State University

Status: Completed

Conditions: Focus of Study: Carotenoid Absorption

Treatments: Other: Carrot; Other: Tomato; Other: Papaya

Study type: Interventional

Funder types: Other

Identifiers

NCT01748916

2011H0336

Details and patient eligibility

About

The goal of this study is to determine if papaya fruits are an exceptionally good food source for carotenoids in humans, particularly when compared more common carotenoid sources like carrots and tomatoes. This objective will be accomplished by quantitation of the immediate post-prandial plasma concentrations of parent carotenoids and vitamin A metabolites from subjects who consumed a meal containing fresh papaya, tomato, and carrot.

Full description

The main purpose of this study is comparing bioavailability of papaya carotenoids versus carrot and tomato carotenoids. Previously, vitamin A deposition in rat livers was studied, showing that carotenoid bioavailability from papaya is higher than from spinach, parsley and carrots. Detailed knowledge about human carotenoid absorption and conversion from papaya fruit compared to other food sources is still lacking.

Enrollment: 16 patients

Sex: All

Ages: 18 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• healthy individuals

Exclusion criteria

• lactating, pregnant, or planned to be pregnant
• smokers/those who use tobacco products
• metabolic or malabsorption disorders
• had a history of cancer
• history of liver insufficiency or other gastro-intestinal diseases
• allergy to papaya, carrots or tomatoes
• obesity

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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16 participants in 6 patient groups

Papaya-Carrot-Tomato

Experimental group

Description:

Test meals were consumed in the following order: 1. Papaya 2. Carrot 3. Tomato.

Treatment:

Other: Papaya

Other: Tomato

Other: Carrot

Papaya-Tomato-Carrot

Experimental group

Description:

Test meals were consumed in the following order: 1. Papaya 2. Tomato 3. Carrot

Treatment:

Other: Papaya

Other: Tomato

Other: Carrot

Tomato-Papaya-Carrot

Experimental group

Description:

Test meals were consumed in the following order: 1. Tomato 2. Papaya 3. Carrot

Treatment:

Other: Papaya

Other: Tomato

Other: Carrot

Tomato-Carrot-Papaya

Experimental group

Description:

Test meals were consumed in the following order: 1. Tomato 2. Carrot 3. Papaya

Treatment:

Other: Papaya

Other: Tomato

Other: Carrot

Carrot-Papaya-Tomato

Experimental group

Description:

Test meals were consumed in the following order: 1. Carrot 2. Papaya 3. Tomato

Treatment:

Other: Papaya

Other: Tomato

Other: Carrot

Carrot-Tomato-Papaya

Experimental group

Description:

Test meals were consumed in the following order: 1. Carrot 2. Tomato 3. Papaya

Treatment:

Other: Papaya

Other: Tomato

Other: Carrot