Comparison of Cervical Pathologies in the Presence of High Risk Hpv Positivity

Kanuni Sultan Suleyman Training and Research Hospital

Status: Completed

Conditions: Human Papilloma Virus; Cervical Neoplasm

Treatments: Diagnostic Test: colposcopy and colposcopic biopsy

Study type: Observational

Funder types: Other

Identifiers

NCT03895905

2018.7.03

Details and patient eligibility

About

The only malignancy screening test among gynecological cancers is cervical cancer.

Cytology examination and Hpv typing with smear are used as screening tests. Hpv positivity is detected in more than 90% of cervical cancers. However, only the Hpv 16-18 type positive patients undergo colposcopy in the routine screening program.

Patients with Smear negative, Type 16-18 high-risk Hpv positivity are evaluated by quota after 1 year.

the authors performed colposcopy with this study; authors aimed to compare the results of patients with type 16-18 Hpv positivity and type 16-18 high-risk Hpv positivity and to find out whether there was any difference between them.

In this way, other high-risk Hpv types other than type 16-18 (31,33,35,45,51, etc.) may be exposed to premalign cervical lesions and possible cancer in a number of earlier and earlier periods by performing colposcopic examination instead of expecting to perform quota after 1 year. we aimed to remove.

Enrollment: 409 patients

Sex: Female

Ages: 20 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 20-65 years old
• patients with normal smear

Exclusion criteria

• Patients with invasive cervical cancer,
• HIV-positive patients,
• ASCUS and more risky premalignant lesions in cytology,
• Over the age of 65 and
• Patients under 20 years of age,
• patients with another known gynecological malignancy

Trial design

409 participants in 2 patient groups

Genotype of HR-HPV 16/18

Description:

Patients with genotype of HR-HPV 16/18 who underwent cervical biopsy with colposcopy

Treatment:

Diagnostic Test: colposcopy and colposcopic biopsy

Genotype of HR-HPV Non-16/18

Description:

Patients with genotype of HR-HPV non-16/18 who underwent cervical biopsy with colposcopy

Treatment:

Diagnostic Test: colposcopy and colposcopic biopsy