Comparison of Cervical Ultrasound and Echoscintigraphy for Preoperative Localization Diagnosis in Primary Hyperparathyroidism (ECHOPARAT)

CHU de Reims

Status: Unknown

Conditions: Primary Hyperparathyroidism

Treatments: Other: cervical ultrasound

Study type: Interventional

Funder types: Other

Identifiers

NCT03605472

PA17094

Details and patient eligibility

About

The biological diagnosis of the primary hyperparathyroidism is now facilitated by the reliability of the balance of phosphate and calcium and the dosage of parathyroid hormone (PTH).

This diagnosis of preoperative localization is important as surgery are now targeted to the responsible lesion.

The "gold standard" for this localization is the cervical ultrasound exploring the usual sites of adenomas and a MIBI scintigraphy (the parathyroid adenoma significantly concentrating this cell marker).

However, the diagnosis of preoperative localization remains a subject of discussion as to the most appropriate tests. Indeed, the morphological diagnosis is performed at the ultrasound stage in more than half the cases. It is the new performance of this morphological examination that makes it possible to obtain these results.

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with primary hyperparathyroidism with surgery indication
• Age > 18yo

Exclusion criteria

• surgical contraindication
• medical treatment by cinacalcet
• non sporadic hyperparathyroidism
• Age <18yo
• Protected by the law

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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100 participants in 1 patient group

Patients

Experimental group

Treatment:

Other: cervical ultrasound