Comparison of Characteristics of Bronchoalveolar Lavage Dusting and of Specific Questionnary Data in Healthy Volunteers and Patients Suffering From Sarcoidosis (MINASARC01)

Centre Hospitalier Saint Joseph Saint Luc de Lyon

Status: Completed

Conditions: Sarcoidosis

Treatments: Other: Bronchoalveolar lavage

Study type: Interventional

Funder types: Other

Identifiers

NCT02863406

MINASARC01

Details and patient eligibility

About

Comparison of dusting rate of bronchoalveolar lavage in healthy volunteers and patients suffering from sarcoidosis.

Blind analysis of bronchoalveolar lavage with Optical Microscopy, Transmission Electron Microscopy and MicroAnalysis.

For patients, comparison of bronchoalveolar lavage, pathological examination of biopsies (Optical Microscopy, Transmission Electron Microscopy and MicroAnalysis) and specific Professional and environmental questionnary.

Healthy volunteers matched with patients regarding to age (every 10 years), sex and tobacco consumption (non-smoking, smoking less than 5 pack-year, smoking between 5 and 10 pack-year, smoking more than 10 pack-year)

Enrollment: 40 patients

Sex: All

Ages: 20 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Absence of respiratory and cardiac illness (healthy volunteers)
• Normal spirometry and chest x-ray (healthy volunteers)
• Absence of viral infection (B and C hepatitis, HIV) (healthy volunteers)
• Confirmation of sarcoidosis (endoscopic exam with bronchoalveolar lavage) (patients suffering from sarcoidosis)

Exclusion criteria

• Pregnant women
• Lack of bronchoalveolar lavage (volume less than 20 ml)

Trial design

Primary purpose: Prevention

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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40 participants in 2 patient groups

Healthy volunteers

Experimental group

Description:

Bronchoalveolar lavage in healthy volunteers

Treatment:

Other: Bronchoalveolar lavage

Patients suffering from sarcoidosis

Experimental group

Description:

Bronchoalveolar lavage in patients suffering from sarcoidosis

Treatment:

Other: Bronchoalveolar lavage