Comparison of Circumferential Pulmonary Vein Isolation Alone Versus Linear Ablation in Addition to Circumferential Pulmonary Vein Isolation for Catheter Ablation in Persistent Atrial Fibrillation: Prospective Randomized Controlled Trial

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Yonsei University

Status

Unknown

Conditions

Atrial Fibrillation

Treatments

Procedure: circumferential pulmonary vein isolation
Procedure: Linear ablation in addiction to circumferential pulmonary vein isolation

Study type

Interventional

Funder types

Other

Identifiers

NCT02721121
4-2016-0029

Details and patient eligibility

About

The purpose of this study is to compare the clinical outcomes depending on catheter ablation strategy for persistent atrial fibrillation. After randomization, investigators will conduct circumferential pulmonary vein isolation alone in a group, and additional posterior box isolation and anterior linear ablation in the other group. Investigators will compare clinical recurrence rate, complication rate, and procedure time, etc.

Enrollment

220 estimated patients

Sex

All

Ages

20 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Patients with persistent Atrial fibrillation (20~80 years)
  • LA diameter <55mm
  • patients possible to anticoagulation and anti arrhythmic drug

Exclusion criteria

  • Structural cardiac disease
  • Contraindication to brain perfusion CT
  • Catheter ablation history for AF,
  • Cardiac surgery for AF
  • active internal bleeding
  • Impossible to anticoagulation or antiarrhythmic drug
  • valvular AF (MA> GII, Mechanical valve, Mitral valve replacement)
  • Patients with severe medical disease
  • Expected survival < 1year
  • Severe alcoholics, drug addiction

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

220 participants in 2 patient groups

circumferential pulmonary vein isolation
Active Comparator group
Description:
circumferential pulmonary vein isolation
Treatment:
Procedure: circumferential pulmonary vein isolation
Linear ablation in addiction to pulmonary vein isolation
Experimental group
Description:
Linear ablation in addiction to pulmonary vein isolation
Treatment:
Procedure: Linear ablation in addiction to circumferential pulmonary vein isolation

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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