Comparison of Circumferential Pulmonary Vein Isolation Alone Versus Linear Ablation in Addition to Circumferential Pulmonary Vein Isolation for Catheter Ablation in Persistent Atrial Fibrillation: Prospective Randomized Controlled Trial

Yonsei University

Status: Unknown

Conditions: Atrial Fibrillation

Treatments: Procedure: circumferential pulmonary vein isolation; Procedure: Linear ablation in addiction to circumferential pulmonary vein isolation

Study type: Interventional

Funder types: Other

Identifiers

NCT02721121

4-2016-0029

Details and patient eligibility

About

The purpose of this study is to compare the clinical outcomes depending on catheter ablation strategy for persistent atrial fibrillation. After randomization, investigators will conduct circumferential pulmonary vein isolation alone in a group, and additional posterior box isolation and anterior linear ablation in the other group. Investigators will compare clinical recurrence rate, complication rate, and procedure time, etc.

Enrollment: 220 estimated patients

Sex: All

Ages: 20 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with persistent Atrial fibrillation (20~80 years)
• LA diameter <55mm
• patients possible to anticoagulation and anti arrhythmic drug

Exclusion criteria

• Structural cardiac disease
• Contraindication to brain perfusion CT
• Catheter ablation history for AF,
• Cardiac surgery for AF
• active internal bleeding
• Impossible to anticoagulation or antiarrhythmic drug
• valvular AF (MA> GII, Mechanical valve, Mitral valve replacement)
• Patients with severe medical disease
• Expected survival < 1year
• Severe alcoholics, drug addiction

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

220 participants in 2 patient groups

circumferential pulmonary vein isolation

Active Comparator group

Description:

circumferential pulmonary vein isolation

Treatment:

Procedure: circumferential pulmonary vein isolation

Linear ablation in addiction to pulmonary vein isolation

Experimental group

Description:

Linear ablation in addiction to pulmonary vein isolation

Treatment:

Procedure: Linear ablation in addiction to circumferential pulmonary vein isolation