Comparison of Clomid and Lezra with Lezra for Ovulation Induction in Clomid Resistant PCOS Case

HITEC-Institute of Medical Sciences

Status and phase: Enrolling; Phase 1

Conditions: Polycystic Ovarian Syndrome

Treatments: Drug: Clomiphene Citrate and letrozole

Study type: Interventional

Funder types: Other

Identifiers

NCT06813118

HITECIMSTAXILLA

Details and patient eligibility

About

Clomiphene citrate resistant i.e failure to ovulate after 6 cycles of ovulation induction effects 15-40% of patients with PCOS.Two treatment groups will be formed one recieving letrozole alone and another recieving CC and letrozole combined.Mature follicles and endometrial thickness will be checked by transvaginal ultrasound and results will be recorded.

Full description

Subfertility is characterized by the inability to achieve conception despite engaging in regular unprotected sexual intercourse for 1-2 years.PCOS exhibits chacteristic traits such as obesity,heightened insulin resistance accompanied by compensatory hyperinsulinemia,oligo/anovulation and subfertility.Clompiphene citrate induces ovarian stimulation.Letrozole ,an aromatase inhibitor emerges as a novel medication with comparable efficacy to CC as a first line treatment for inducing ovulation in cases of anovulation.

Enrollment: 42 estimated patients

Sex: Female

Ages: 20 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• women of 20-40 years with a history of PCOS and resistant to CC

Exclusion criteria

• Premature ovarian insufficiency
• Husband has oligo azoospermia
• Hypothyroidism
• Hyperprolactinemia

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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42 participants in 2 patient groups

group 1

Experimental group

Description:

clomiphene citrate and letrozole combination

Treatment:

Drug: Clomiphene Citrate and letrozole

group 2

Experimental group

Description:

letrozole alone

Treatment:

Drug: Clomiphene Citrate and letrozole