Comparison of Clopidogrel and Ticagrelor on Microvascular Dysfunction in ST-Segment Elevation Myocardial Infarction

Inha University Hospital

Status and phase

Completed

Phase 4

Conditions

ST Segment Elevation Myocardial Infarction

Non-ST Segment Elevation Myocardial Infarction

Treatments

Drug: Ticagrelor

Drug: Clopidogrel

Study type

Interventional

Funder types

Other

Identifiers

NCT02026219

IUH-IRB-13-2256

Details and patient eligibility

About

Ticagrelor is a non-thienophyridine, direct P2Y12 blocker that is more potent than clopidogrel and is associated with less interindividual variability. In the PLATO trial, it was found to be superior to clopidogrel with respect to cardiovascular outcomes and total mortality without increasing the risk of bleedings.

More potent and reversible receptor bindings are possible explanation for the superior outcomes. Beside the potent effect on inhibition of antiplatelet function, ticagrelor has previously been demonstrated to increase adenosine levels by inhibiting adenosine re-uptake in tissue level and can induce adenosine triphosphate (ATP) release from human red cells, which both stimulate vasodilation of in red blood cells.

Enrollment

76 patients

Sex

All

Ages

18 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:
- Males and Females
- between the ages of 18 and 75 years
- STEMI patients treated with percutaneous coronary intervention
- Able to provide informed consent
Exclusion Criteria:
- History of stroke or transient ischemic attack
- Platelet count < 100 000/μL
- Known Bleeding Diathesis
- Hematocrit <30% or >52%
- Severe Liver Dysfunction
- Renal Insufficiency (Creatinine Clearance < 30ml/min)
- Pregnant females
- Cardiogenic shock or symptomatic hypotension or sitting SBP < 95 mmHg