Comparison of Co2 Laser Versus Co2 Laser With PRP in Scars

Combined Military Hospital Abbottabad

Status and phase: Completed; Phase 1

Conditions: CO2 Laser in Scars

Treatments: Procedure: Fractional CO2 laser; Procedure: Fractional CO2 with Platelet Rich Plasma

Study type: Interventional

Funder types: Other

Identifiers

NCT05887232

CMHAbbottabad1988

Details and patient eligibility

About

Objective: To compare the effect of Fractional Carbon dioxide Laser (FCL) Vs Fractional Carbon dioxide Laser with platelet rich plasma (PRP) in management of Scars.

Study design: Randomized-controlled trial (RCT). Study setting and duration: Dermatology Department, CMH-Abbottabad, November 2022/April 2023.

Methodology: The sample size of 60 patients, age 18 to 50 years, was calculated by using Openepi app and the non-probability consecutive sampling technique was used. Patient in group A received FCL treatment's four sessions with four weeks apart, whereas Group B received four PRP and FCL sessions. The Quartile grading scale (score 0 is <25%, score 1 is 25-50%, score 2 is 51-75% and score 3 is >75% improvement) was used to assess the patient's clinical improvement at 4 weeks after each session. To determine statistical significance χ2-square test, taking p-value <0.05 as significant, was used.

Enrollment: 60 patients

Sex: All

Ages: 18 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients aged 18-50 years
• Fitzpatrick skin type III-V
• Presented with post-acne, post traumatic or post burn scars
• all those patients emotionally balanced with realistic expectations were included in the study.

Exclusion criteria

• scar that was less than 6 months old
• if they had an active infection or inflammatory skin condition
• having a history of malignancy
• a known connective tissue illness
• history of excessive bleeding or keloids
• unrealistic expectations
• pregnant or breastfeeding.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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60 participants in 2 patient groups

Fractional Co2 laser

Active Comparator group

Description:

Patient in group A received FCL treatment's four sessions four weeks apart.

Treatment:

Procedure: Fractional CO2 laser

Platelet Rich Plasma

Active Comparator group

Description:

Group B received fractional CO2 with four Platelet Rich Plasma sessions,4 weeks apart.

Treatment:

Procedure: Fractional CO2 with Platelet Rich Plasma