Comparison of Complement Factors and Genetic Polymorphisms of AMD Between Patients With Systemic Lupus Erythematosus (SLE) With and Without Retinal "Pseudo-drusen-like" Deposits: Case-control Study (PL-AMD)

F

Fondation Ophtalmologique Adolphe de Rothschild

Status

Completed

Conditions

Age Related Macular Degeneration
Lupus Erythematosus, Systemic
Lupus Erythematosus

Treatments

Procedure: Blood test

Study type

Observational

Funder types

NETWORK

Identifiers

NCT03504540
MMT_2018_1

Details and patient eligibility

About

The rationale of this research is to determine if patients with lupus and presenting retinal "pseudo-drusen-like" deposits have genetic and complement-related similarities with AMD patients. Based on the results obtained, this study could lead to future research that could better target the treatment of patients with lupus or patients with AMD (Age related Macular Degeneration). The primary objective is to check if patients with lupus, treated or not with antimalarial drugs, with "pseudo-drusen-like" deposits have a different complement profile (functional exploration of complement, complement factors, genetic complement polymorphisms involved in AMD) compared to patients without "pseudo-drusen-like" deposits.

Enrollment

42 patients

Sex

All

Ages

18 to 50 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Systemic lupus erythematosus
  • Case patients : with "pseudo-drusen-like" deposit
  • Control patients : without "pseudo-drusen-like" deposit

Exclusion criteria

  • Patient under a measure of legal protection

Trial design

42 participants in 2 patient groups

Case (with pseudo-drusen-like deposits)
Description:
Patients with lupus, treated or not with antimalarial drugs, with "pseudo-drusen-like" deposits
Treatment:
Procedure: Blood test
Control (without pseudo-drusen-like deposits)
Description:
Patients with lupus, treated or not with antimalarial drugs, without "pseudo-drusen-like" deposits
Treatment:
Procedure: Blood test

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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