Comparison of Complement Factors and Genetic Polymorphisms of AMD Between Patients With Systemic Lupus Erythematosus (SLE) With and Without Retinal "Pseudo-drusen-like" Deposits: Case-control Study (PL-AMD)

Fondation Ophtalmologique Adolphe de Rothschild

Status: Completed

Conditions: Age Related Macular Degeneration; Lupus Erythematosus, Systemic; Lupus Erythematosus

Treatments: Procedure: Blood test

Study type: Observational

Funder types: NETWORK

Identifiers

NCT03504540

MMT_2018_1

Details and patient eligibility

About

The rationale of this research is to determine if patients with lupus and presenting retinal "pseudo-drusen-like" deposits have genetic and complement-related similarities with AMD patients.

Based on the results obtained, this study could lead to future research that could better target the treatment of patients with lupus or patients with AMD (Age related Macular Degeneration).

The primary objective is to check if patients with lupus, treated or not with antimalarial drugs, with "pseudo-drusen-like" deposits have a different complement profile (functional exploration of complement, complement factors, genetic complement polymorphisms involved in AMD) compared to patients without "pseudo-drusen-like" deposits.

Enrollment: 42 patients

Sex: All

Ages: 18 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Systemic lupus erythematosus
• Case patients : with "pseudo-drusen-like" deposit
• Control patients : without "pseudo-drusen-like" deposit

Exclusion criteria

• Patient under a measure of legal protection

Trial design

42 participants in 2 patient groups

Case (with pseudo-drusen-like deposits)

Description:

Patients with lupus, treated or not with antimalarial drugs, with "pseudo-drusen-like" deposits

Treatment:

Procedure: Blood test

Control (without pseudo-drusen-like deposits)

Description:

Patients with lupus, treated or not with antimalarial drugs, without "pseudo-drusen-like" deposits

Treatment:

Procedure: Blood test