Comparison of Conventional Triple Therapy Versus Sequential Therapy for H. Pylori in Peptic Ulcer Disease: Prospective Randomized Trial

Jun-Won Chung

Status and phase: Completed; Phase 4

Conditions: Helicobacter Infected Patients

Treatments: Drug: sequential versus triple

Study type: Interventional

Funder types: Industry

Identifiers

NCT01418300

GMC2010-088

Details and patient eligibility

About

The purpose of this study is to improve first line Helicobacter pylori eradication rate and to compare the sequential versus conventional triple therapy.

Enrollment: 159 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• peptic ulcer diseae
• two test positive rapid urease test, culture, histology

Exclusion criteria

• lactating or pregnant
• previous stomach surgery
• severe underlying disease

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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159 participants in 2 patient groups

sequential therapy

Active Comparator group

Description:

first five day amoxicillin+PPI later five day PPI+clarithromycin+metronidazole

Treatment:

Drug: sequential versus triple

conventional triple thearpy

Active Comparator group

Description:

PPI+amoxicillin+clarithromycin

Treatment:

Drug: sequential versus triple