Comparison of Cryotherapy and Peeling Agent in the Treatment of Common Warts

Combined Military Hospital Abbottabad

Status: Completed

Conditions: Warts

Treatments: Drug: CRYOTHERAPY; Drug: Tricholoracetic acid

Study type: Interventional

Funder types: Other

Identifiers

NCT05712811

CMHAbbottabad

Details and patient eligibility

About

Objective: To compare the efficacy of cryotherapy using liquid nitrogen (cryoget method) versus trichloroacetic acid 90% (applicator method) in treatment of common warts.

Study Design: Randomized Control Trial. Place And Duration of Study: Department of Dermatology, CMH Abbottabad from Jun 2022 to Nov, 2022.

Full description

A total of 60 patients were enrolled in this investigation by non-probability consecutive sampling technique. Sample size was calculated using WHO sample size calculator and patients were randomized into two equal groups, A and B, each comprising of 30 patients through lottery method. Patients with common warts such as hard lesions, raised lumps with rough surfaces at the back of their fingers, around nails and palm of their hands between the ages of 18 and 60 were included, whereas those with genital warts, cardiac, hepatic, renal, or hypercholesterolemia were excluded.

Enrollment: 60 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patient presented with common warts in dermatology opd

Exclusion criteria

• • Patients with warts on toes and tip of fingers

  • genital warts
  • cardiac, hepatic and renal disease
  • hypercholesterolemia
  • hypersensitivity reactions

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

---

60 participants in 2 patient groups

Group A cryotherapy

Active Comparator group

Description:

Cryotherapy Group A had their warts treated once every two weeks for a total of twelve weeks, with liquid nitrogen using cryoget method for 10 to 15 seconds on each lesion (depending on size, until a narrow white rim of around 1 mm developed around it).

Treatment:

Drug: CRYOTHERAPY

Group B Topical TCA 90%

Active Comparator group

Description:

Topical TCA 90 % Warts in Group B were treated with liquid TCA 90% by an applicator every two weeks for a total of twelve weeks. After 20 minutes, patients were instructed to remove the solution by washing their warts with water or regular saline

Treatment:

Drug: Tricholoracetic acid