Comparison of Deep Extubation During Emergence Using Desflurane or Desflurane With Remifentanil in Patients Undergoing General Anesthesia

Chung-Ang University Hosptial, Chung-Ang University College of Medicine

Status and phase: Completed; Phase 4

Conditions: Deep Extubation

Treatments: Drug: Desflurane; Drug: Desflurane with remifentanil

Study type: Interventional

Funder types: Other

Identifiers

NCT01924871

deep extubation in CAUH

Details and patient eligibility

About

It has been reported that deep extubation can reduce cardiopulmonary complication against endotracheal tube extubation during emergence from general anesthesia. The investigators hypothesized that using desflurane with target controlled infusion of remifentanil is more effective than using desflurane alone during deep extubation. The purpose of this study is to evaluate the effect of remifentanil to prevent respiratory complication (etc. coughing) during emergence from general anesthesia.

Enrollment: 62 patients

Sex: All

Ages: 20 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 20-60
• patients undergoing elective surgery take more than an hour
• Under general anesthesia using an LMA
• ASA I,II

Exclusion criteria

• Patients on CNS depressants
• Chronic opioid use
• Corticosteroid
• Pregnant patients
• Full stomach
• Morbidly obese (BMI >35kg/m2)
• Hepatitis B
• Hepatitis C
• Coronary artery disease
• Liver disease
• Renal disease
• Seizure disorder

Dropout criteria:

• Need for reintubation due to breath holding
• high ETCO2 during self ventilation (ETCO2>50)
• Surgeon or patient request

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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62 participants in 2 patient groups

Desflurane group

Active Comparator group

Description:

1.5 MAC desflurane until extubation

Treatment:

Drug: Desflurane

Desflurane with remifentanil group

Active Comparator group

Description:

1.0 MAC desflurane with 1.0ng/ml targeted concentration infusion of remifentanil

Treatment:

Drug: Desflurane with remifentanil