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Comparison of Deep Extubation During Emergence Using Desflurane or Desflurane With Remifentanil in Patients Undergoing General Anesthesia

C

Chung-Ang University Hosptial, Chung-Ang University College of Medicine

Status and phase

Completed
Phase 4

Conditions

Deep Extubation

Treatments

Drug: Desflurane
Drug: Desflurane with remifentanil

Study type

Interventional

Funder types

Other

Identifiers

NCT01924871
deep extubation in CAUH

Details and patient eligibility

About

It has been reported that deep extubation can reduce cardiopulmonary complication against endotracheal tube extubation during emergence from general anesthesia. The investigators hypothesized that using desflurane with target controlled infusion of remifentanil is more effective than using desflurane alone during deep extubation. The purpose of this study is to evaluate the effect of remifentanil to prevent respiratory complication (etc. coughing) during emergence from general anesthesia.

Enrollment

62 patients

Sex

All

Ages

20 to 60 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Age 20-60
  • patients undergoing elective surgery take more than an hour
  • Under general anesthesia using an LMA
  • ASA I,II

Exclusion criteria

  • Patients on CNS depressants
  • Chronic opioid use
  • Corticosteroid
  • Pregnant patients
  • Full stomach
  • Morbidly obese (BMI >35kg/m2)
  • Hepatitis B
  • Hepatitis C
  • Coronary artery disease
  • Liver disease
  • Renal disease
  • Seizure disorder

Dropout criteria:

  • Need for reintubation due to breath holding
  • high ETCO2 during self ventilation (ETCO2>50)
  • Surgeon or patient request

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Triple Blind

62 participants in 2 patient groups

Desflurane group
Active Comparator group
Description:
1.5 MAC desflurane until extubation
Treatment:
Drug: Desflurane
Desflurane with remifentanil group
Active Comparator group
Description:
1.0 MAC desflurane with 1.0ng/ml targeted concentration infusion of remifentanil
Treatment:
Drug: Desflurane with remifentanil

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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