Comparison of Dentin Hypersensitivity Reduction Over a 1-month Period

King Abdulaziz University

Status: Completed

Conditions: Dentin Sensitivity

Treatments: Other: Gluma; Other: Tetric N-Bond self-etch adhesive; Other: fluoride varnish

Study type: Interventional

Funder types: Other

Identifiers

NCT04351412

129-09-19

Details and patient eligibility

About

Here we assessed the clinical effectiveness of Gluma, fluoride varnish, and the Tetric N-Bond one-step self-etch system in alleviating DH instantly and over 1 month, after a single topical application.A randomized, double-blind, clinical trial was conducted on 55 patients (25 males, 30 females; age: 20-49 years). Seventy teeth were randomly assigned to three groups: Gluma (n = 24); fluoride varnish (n = 23); and Tetric N-Bond adhesive (n = 23). Sensitivity to tactile, air blast, and cold stimuli were investigated.. A visual analogue scale was used to assess tactile stimuli, and the Schiff Cold Scale to assess air blast and cold stimuli. DH was evaluated immediately post-treatment, and at the 2-week and 1-month follow-up. Between-group and within-group comparisons were made.

Enrollment: 55 patients

Sex: All

Ages: 20 to 49 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Middle-aged adult population who usually complains of Dentin Hypersensitivity.
• Age range 20-49 years, that visit the dental hospital at King Abdul-Aziz university (KAUDH) who would have at least one or two teeth with DH
• Those with recession of the gingiva, teeth erosion or abrasion.
• Patients agreed to participate in the study.

Exclusion criteria

• Patients going through professional desensitizing treatment during the previous three months; Using desensitizing tooth paste in the last two months
• Chronic; far on progress periodontal disease; treatment for periodontal disease;
• Teeth with ICDAS (International Caries Detection and Assessment System) score 4
• Teeth diagnosed for irreversible pulpitis; root canal treated teeth
• Teeth covered with crowns; bridge
• Teeth with cervical restorations interfering with the evaluation
• Medically compromised patients currently using medications like anticonvulsants, antihistamines, antidepressants, sedatives or daily analgesics.
• Pregnant or lactating women; were also excluded.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

---

55 participants in 3 patient groups

Tactile stimulus

Active Comparator group

Description:

The tactile stimulus was examined using an explorer (# 17/23), passing at a right angle to the bucco-cervical tooth surface of concern. Contributors evaluated participants' pain score on a 10-point visual analogue scale (VAS). The stimulus was used to assess dentine hypersensitivity at baseline and immediately after completion of treatment. Subjects were also recalled for re-evaluation at 2 weeks and at 1 month after desensitizing treatment.

Treatment:

Other: Tetric N-Bond self-etch adhesive

Other: fluoride varnish

Other: Gluma

Air blast stimulus

Active Comparator group

Description:

For air blast stimuli, air was delivered by a three-way syringe from a typical dental unit air syringe at 40 psi (± 10 psi) and 70 °F (± 5 °F). The air flow was aimed at the tooth surface of concern, for 1 second, from a distance of 1 cm. The air blast stimulus scores were assessed by the Schiff Cold Air Sensitivity Scale 18. DH was assessed for air blast stimuli at baseline and immediately after completion of treatment. Subjects were also recalled for re-evaluation at 2 weeks and at 1 month after desensitizing treatment.

Treatment:

Other: Tetric N-Bond self-etch adhesive

Other: fluoride varnish

Other: Gluma

Cold stimulus

Active Comparator group

Description:

For cold hypersensitivity assessment, the tooth was isolated using cotton rolls; then, a few drops of extremely cold water were delivered to the tooth from a syringe that had previously been cooled. The cold stimulus scores were assessed by the Schiff Cold Air Sensitivity Scale 18. DH was assessed for cold stimulus at baseline and immediately after completion of treatment. Subjects were also recalled for re-evaluation at 2 weeks and at 1 month after desensitizing treatment.

Treatment:

Other: Tetric N-Bond self-etch adhesive

Other: fluoride varnish

Other: Gluma