Comparison of Desflurane With Sevoflurane for School-age Children in Postoperative Cognitive Function

China Medical University

Status: Unknown

Conditions: Postoperative Cognitive Dysfunction

Treatments: Drug: Desflurane; Drug: sevoflurane

Study type: Interventional

Funder types: Other

Identifiers

NCT02909413

DES VS. SEV

Details and patient eligibility

About

This study compares desflurane with sevoflurane for school-age children in postoperative cognitive function.

Full description

The postoperative cognitive dysfunction (POCD) of school-age children (6-14 age) after operation draw more attention from both society and family. It is well known that, compare with sevoflurane, desflurane could improve cognitive function in elderly patients. But whether Desflurane could improve postoperative cognitive function compare with Sevoflurane for the school-age children, there is no consistent conclusion.

Enrollment: 600 estimated patients

Sex: All

Ages: 6 to 14 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 6-14 age, elective no-cardiac and non-neurological surgery , ASA physical statusⅠorⅡ, no preoperative cognitive function impairment, cooperate to complete the entire test.

Exclusion criteria

• Allergic to halogens inhaled anesthetics, malignant hyperthermia susceptible patients, intracranial hypertension, emotional disorder, hyperactivity, history of operation, mental retardation, audio-visual obstacles, history of congenital heart disease, Important organ dysfunction, history of drug abuse
• History of epilepsy
• Preoperative respiratory infection significantly.

Trial design

Primary purpose: Health Services Research

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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600 participants in 2 patient groups

Group Desflurane

Experimental group

Description:

Anesthesia maintenance: After endotracheal intubation, patients will be randomized into Desflurane for maintenance. The gas flow rate of Desflurane group is 2 L/min, include 50％ O2 and 4～5％ Desflurane.

Treatment:

Drug: Desflurane

Group Sevoflurane

Active Comparator group

Description:

Anesthesia maintenance: After endotracheal intubation, patients will be randomized into sevoflurane for maintenance. The gas flow rate of Sevoflurane group is 2L/ min, include 50％O2 and 1.7-2.0% Sevoflurane.

Treatment:

Drug: sevoflurane