Comparison of Detection and Miss Rates of Blue Laser Imaging Versus Conventional White Light Colonoscopy

Yangzhou No.1 People's Hospital

Status: Unknown

Conditions: Colorectal Adenoma

Treatments: Device: conventional white light colonoscopy; Device: blue laser imaging colonoscopy

Study type: Interventional

Funder types: Other

Identifiers

NCT02982447

Yangzhou1PH

Details and patient eligibility

About

It is a randomized controlled trial with tandem colonoscopy.Participants were randomized for use of either blue laser imaging or conventional White Light Colonoscopy on withdrawal method.comparison of detection and miss rates of BLI group Versus conventional White Light Colonoscopy.

Full description

blue laser imaging (BLI) are a new imaging systems used in endoscopy which are recently developed. According to three recently published reports, the diagnostic ability of adenoma characterization using blue laser imaging compares favorably with narrow band imaging. No published data are available to date regarding adenoma detection with blue laser imaging.BLI has the possibility to increase the detection of colorectal polyps by sufficient brightness and clearer endoscopic images.The investigators recruited participants who underwent colonoscopy for symptoms,screening,or surveillance.Participants were randomized for use of either blue laser imaging (BLI) or conventional white light colonoscopy on withdrawal method.Lesions detected on first-pass and second-pass examination were used for adenoma detection and miss rates,respectively.The primary outcomes is to compare the adenoma and poly detection rates of BLI with conventional white light Colonoscopy.

Enrollment: 420 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• consecutive patients who were underwent colonoscopy in our center for diagnostic work up of colonic symptoms,surveillance of colorectal polyps, and colorectal cancer screening.

Exclusion criteria

• history of colon cancer, colectomy familial adenomatous polyposis, or inflammatory bowel diseases;
• severe intestinal stenosis or obstruction;coagulation，disorders;
• pregnancy;
• and colonoscopy examinations with inadequate bowel cleanliness

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: None (Open label)

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420 participants in 2 patient groups

Blue Laser Imaging colonoscopy

Active Comparator group

Description:

Insertion to cecum was performed under white light(WL) and once the cecum was reached, the Blue Laser Imaging mode was switched on during withdrawal of endoscope for complete colonic examination. Second colonoscopic examination was performed in a similar manner after the first complete withdrawal of the colonoscope. WL was used on insertion and WL was used on withdrawal

Treatment:

Device: blue laser imaging colonoscopy

conventional white light colonoscopy

Experimental group

Description:

In this arm, WL was used for both insertion and withdrawal of the colonoscope during the first-pass and second-pass examinations.

Treatment:

Device: conventional white light colonoscopy