Comparison of Dexmedetomidine and Propofol on the Delirium and Neuroinflammation in Patients With SIRS.

Moscow Regional Research and Clinical Institute (MONIKI)

Status and phase: Withdrawn; Phase 4

Conditions: Delirium

Treatments: Drug: Propofol; Drug: Dexmedetomidine

Study type: Interventional

Funder types: Other

Identifiers

NCT02366299

D-P-SIRS-220115

Details and patient eligibility

About

Assessment of sedative effects of dexmedetomidine and propofol on the clinical course of delirium and neuroinflammation in patients with SIRS using CAM-ICU scale and protein S100b in serum.

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• presence of delirium

Exclusion criteria

• presence of Alzheimer's disease
• any mental disorder
• presence of cancer

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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0 participants in 2 patient groups

dexmedetomidine

Active Comparator group

Description:

Treatment of delirium by dexmedetomidine i.v. infusion

Treatment:

Drug: Dexmedetomidine

propofol

Active Comparator group

Description:

Treatment of delirium by propofol i.v. infusion

Treatment:

Drug: Propofol