COMPARISON OF DEXMEDETOMIDINE AND REMIFENTANIL FOR POSTOPERATIVE PAIN IN TRANSPHENOIDAL Pituitary SURGERY

Kocaeli University

Status: Completed

Conditions: Postoperative Pain

Treatments: Drug: Remifentanyl; Drug: Dexmedetomidine

Study type: Observational

Funder types: Other

Identifiers

NCT05772832

KocaeliUI

Details and patient eligibility

About

In patients with pituitary adenoma scheduled for endoscopic transsphenoidal pituitary surgery, it was aimed to compare the efficacy of postoperative pain relief of a selective α-2 agonist "Dexmedetomidine" and the rapid and short-acting opioid "Remifentanil" using the "Numerical Rating Scale" (NRS) administered alongside propofol in perioperative maintenance anesthesia. .

Enrollment: 104 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 18-65 years old
• ASA-1 and ASA-2 patients

Exclusion criteria

• Patients in need of postoperative intensive care

Trial design

104 participants in 2 patient groups

GROUP USING REMIFENTANYL

Description:

THE GROUP USING PEROPERATIVE REMIFENTANYL AND PROPOFOL IN TRANSSPHENOIDAL Pituitary Surgery 0.01-0.2 μg /kg /min Remifentanyl and 3-12 mg/kg/h propofol

Treatment:

Drug: Remifentanyl

GROUP USING DEXMEDETOMIDINE

Description:

THE GROUP USING PEROPERATIVE DEXMEDETOMIDINE AND PROPOFOL IN TRANSSPHENOIDAL Pituitary Surgery 0.01-0.02 μg/kg/min (\~0.5 μg/kg/h) continuous infusion of dexmedetomidine 1 mcg/kg 10 minutes after a loading dose and 3-12 mg/kg/h propofol

Treatment:

Drug: Dexmedetomidine