Comparison Of Dexmedetomidine, Fentanyl And Lignocaine In Attenuation Of Hemodynamic Response To Direct Laryngoscopy And Intubation In Patient Undergoing Laparoscopic Cholecystectomy

Sana Urooj

Status: Unknown

Conditions: Laparoscopic Cholecystectomy

Treatments: Drug: fentanyl; Drug: lidocaine; Drug: dexmedetomidine

Study type: Interventional

Funder types: Other

Identifiers

NCT04138472

3

Details and patient eligibility

About

Comparison Of Dexmedetomidine, Fentanyl And Lignocaine In Attenuation Of Hemodynamic Response To Direct Laryngoscopy And Intubation In Patient Undergoing Laparoscopic Cholecystectomy

Full description

Direct laryngoscopy and intubation are painful stimulus that activates sympathoadrenal discharge which results in intense cardiovascular reflex i.e. tachycardia and hypertension. In this study we will compare effects of intravenous dexmedetomidine, fentanyl and lidocaine for attenuation of these reflexes in patient undergoing laproscopic cholecystectomy. how these agents will effect hemodynamic response during pneumoperitoneum. Tertiary objective will be to observe sedation, perioperative complications and recovery in these patients.

Enrollment: 30 estimated patients

Sex: All

Ages: 20 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA-I and ll patients
• Male and female patient of age 20-70 years.
• Undergoing Elective surgery
• Intubation by skilled anesthetist of at least 2 years' experience
• Intubation not more than 45 seconds

Exclusion criteria

• Patients with uncontrolled DM, HTN, IHD, endocrine or autonomic dysfunction
• Pregnant and lactating females
• Short thick neck with anticipated difficult intubation
• Any sort of obstructive restrictive or reactive airway disease
• Patient allergic to any of the study medications.
• Obese patients, Narcotic addicts

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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30 participants in 3 patient groups

Dexmedetomidine

Experimental group

Description:

Group A patients receive intravenous dexmedetomidine 0.06mg/kg in 100ml normal saline 0.9% over 10minutes.

Treatment:

Drug: dexmedetomidine

Fentanyl

Experimental group

Description:

Group B receives intravenous fentanyl at 2mcg/kg in 100ml saline over 10 minutes in induction room.

Treatment:

Drug: fentanyl

Lidocaine

Experimental group

Description:

Group C patients receives intravenous lidocaine 1.5mg/kg in 100ml saline over 10 minutes in induction room.

Treatment:

Drug: lidocaine