Comparison of Dialysis Strategies in Critically Ill Patients With Acute Renal Failure (rescue)

Heidelberg University

Status: Completed

Conditions: Dialysis; Acute Renal Failure

Treatments: Procedure: Renal replacement therapy

Study type: Interventional

Funder types: Other

Identifiers

NCT00322530

HD-Dialysis-2006

Details and patient eligibility

About

The goal of the present study is the comparison of different dialysis strategies in critically ill patients with acute renal failure on the intensive care unit. Patients are treated with either continuous dialysis or hemofiltration. Outcome measures are death, restitution of renal function, days on ICU, hemodynamic stability, dialysis efficiency.

Full description

The goal of the present study is the comparison of different renal replacement strategies in critically ill patients with acute renal failure on the intensive care unit. In a prospectively randomized clinical study patients are treated with either continuous dialysis (SLED) or continuous hemofiltration (CVVHD). 200 patients should be included in the study (n=100 each). The primary outcome is death at ICU, secondary outcome measures are restitution of renal function, days on ICU, hemodynamic stability, dialysis efficiency.

Enrollment: 230 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients 18 years or older
• Written informed consent
• No pre-existing dialysis dependency

Exclusion criteria

• Minors / children
• No consent
• Severe electrolyte disturbances which necessitates special dialysis therapy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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230 participants in 2 patient groups

SLED

Active Comparator group

Treatment:

Procedure: Renal replacement therapy

CVVHD

Active Comparator group

Treatment:

Procedure: Renal replacement therapy