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Comparison of Dietary Fats on Vascular Parameters (COIL)

U

Unity Health Toronto

Status

Unknown

Conditions

Healthy

Treatments

Other: Chia Oil
Other: Coconut Oil
Other: Grapeseed Oil
Other: Butter
Other: Canola Oil

Study type

Interventional

Funder types

Other

Identifiers

NCT01876394
COIL

Details and patient eligibility

About

The purpose of the study is to examine the effect of consuming 50g of fat from 5 different sources (coconut, canola, grapeseed, chia, and butter) on arterial stiffness, blood pressure and blood glucose levels. It is hypothesized that butter will have the most detrimental effect on acute vascular function. Canola, grapeseed and chia oil with their decreased content of SFA are hypothesized to impair vascular function to a lesser extent.

Enrollment

24 estimated patients

Sex

All

Ages

18 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Healthy
  • Age 18-65 years
  • BMI < 30 kg/m2
  • Brachial systolic blood pressure ≤ 140 mmHg
  • Brachial diastolic blood pressure ≤ 90 mmHg

Exclusion criteria

  • Women of childbearing age must not be pregnant or breastfeeding at the time of the study
  • BMI >35kg/m2
  • Hypertensive as defined by brachial SBP >140mmHg and/or DBP >90mmHg
  • Sensitivity to the study product or its sources
  • Presence of chronic conditions or illnesses
  • Having any gastrointestinal complication or condition
  • Chronic use of dietary supplements that alter fat absorption

Trial design

24 participants in 5 patient groups, including a placebo group

Coconut oil
Experimental group
Treatment:
Other: Grapeseed Oil
Other: Coconut Oil
Other: Chia Oil
Other: Butter
Other: Canola Oil
Canola oil
Experimental group
Treatment:
Other: Grapeseed Oil
Other: Coconut Oil
Other: Chia Oil
Other: Butter
Other: Canola Oil
Grapeseed oil
Experimental group
Treatment:
Other: Grapeseed Oil
Other: Coconut Oil
Other: Chia Oil
Other: Butter
Other: Canola Oil
Chia oil
Experimental group
Treatment:
Other: Grapeseed Oil
Other: Coconut Oil
Other: Chia Oil
Other: Butter
Other: Canola Oil
Butter
Placebo Comparator group
Treatment:
Other: Grapeseed Oil
Other: Coconut Oil
Other: Chia Oil
Other: Butter
Other: Canola Oil

Trial contacts and locations

1

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Central trial contact

Thanh Ho, BSc

Data sourced from clinicaltrials.gov

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