Comparison of Difference Histamine Concentration (1, 5 and 10 mg/ml) for Skin Prick Test Positive Control

Mahidol University

Status: Completed

Conditions: Immediate Hypersensitivity

Treatments: Procedure: SPT

Study type: Interventional

Funder types: Other

Identifiers

NCT02561429

si645/2012

Details and patient eligibility

About

Skin prick test (SPT) was used for diagnostic test for type 1 hypersensitivity. The efficacy and safety of SPT were proved. The positive control of SPT is histamine.

In Thailand, the most common concentration of histamine for SPT is 10 mg/ml. However, in some practice they use other concentration (1, 2.5 mg/ml).

This study will find the proper concentration of histamine for positive control use in SPT.

Full description

Appropriate concentration of histamine positive control is important in interpretation the result of skin prick test.

Enrollment: 180 patients

Sex: All

Ages: 7 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Parcitipate person who attented allergy clinic, ENT clinic
• Legible in Thai language

Exclusion criteria

• Patient cannot withhold antihistamine drug
• Pragnancy and lactation mother
• comorbid disease such as cardiac disease, liver, renal, hypertension and severe asthma

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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180 participants in 1 patient group

SPT of histamine

Experimental group

Description:

SPT of histamine concentration 1, 5 and 10 mg/ml

Treatment:

Procedure: SPT