Comparison of Different Concentrations of Carbamide as Moisturizers in Ichthyosis Vulgaris (Urea-IV)

University of Aarhus

Status: Unknown

Conditions: Ichthyosis Vulgaris

Treatments: Device: 7.5 %

Study type: Interventional

Funder types: Other

Identifiers

NCT02978209

UFKOPAUH201601

Details and patient eligibility

About

A randomized double blinded clinical trial will be conducted comparing the effect of two simple basic moisturizers only different in the concentration of carbamide (urea). The concentrations of carbamide will be tested are 0 and 7.5, respectively. The study will be conducted as a split-body-study and will contain two arms randomized to comparing 0 and 7.5 % carbamide, respectively. Approximately 20 patients with at least clinically verified Ichthyosis Vulgaris will be enrolled to each study arm. The effect of the moisturizers will be assessed by clinical examination (score), patients assesment of effect and measurement of transepidermal water loss (TEWL) and other skin parameters.

Enrollment: 20 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Clinically diagnosed with Ichthyosis Vulgaris

Exclusion criteria

• All other forms of Ichthyosis

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Double Blind

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20 participants in 2 patient groups

Only moisturizer, no carbamide

No Intervention group

Description:

20 patients with Ichthyosis Vulgaris at age 0-80 years old. One body half

Moisturizer + 7,5 % carbamide

Active Comparator group

Description:

20 patients with Ichthyosis Vulgaris at age 0-80 years old. Other body half

Treatment:

Device: 7.5 %