Comparison of Different Inspiratory to Expiratory Ratios on Respiratory Mechanics and Oxygenation in Robot-assisted Laparoscopic Radical Prostatectomy With Steep Trendelenburg Position and Pneumoperitoneum

Yonsei University

Status: Completed

Conditions: General Anesthesia Using Endotracheal Intubation

Treatments: Other: conventional I:E ratio (1:2); Other: prolonged inspiratory to expiratory (I:E) ratio (1:1)

Study type: Interventional

Funder types: Other

Identifiers

NCT01892449

4-2013-0287

Details and patient eligibility

About

The steep trendelenburg position and pneumoperitoneum during laparoscopic surgery have the potential to cause an adverse effects on respiratory mechanics and gas exchange. Previous studies have proposed that a prolonged I:E ratio ventilation improved respiratory mechanics and gas exchange. Therefore, the aim of this study is to evaluate whether a prolonged I:E ratio ventilation improves gas exchange and respiratory mechanics in patients undergoing robot-assisted laparoscopic radical prostatectomy.

Enrollment: 80 patients

Sex: Male

Ages: 20 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult male patients (20-90 years of age) scheduled for elective robot-assisted laparoscopic radical prostatectomy undergoing general anesthesia

Exclusion criteria

• Patients with an abnormal airway anatomy, reactive airway diseases, chronic respiratory diseases, a history of coronary artery diseases, or heart failure
• BMI > 30 kg/m 2

Trial design

80 participants in 2 patient groups

prolonged I:E ratio (1:1) group

Experimental group

Treatment:

Other: prolonged inspiratory to expiratory (I:E) ratio (1:1)

conventional I:E ratio (1:2) group

Active Comparator group

Treatment:

Other: conventional I:E ratio (1:2)