Comparison of Different Mucoactive Agents for the Care of the Intubated Patient in a Surgical Trauma Intensive Care Unit

The University of Texas System (UT)

Status: Completed

Conditions: Mucus Obstruction; Intubation

Treatments: Drug: sodium chloride (saline); Drug: mucomyst

Study type: Interventional

Funder types: Other

Identifiers

NCT00131521

034-1502-320

Details and patient eligibility

About

This study compares N-acetylcysteine (mucomyst) and sodium chloride to determine their efficacy in the prevention of pulmonary mucus obstruction and retention in intubated patients admitted to the surgical trauma intensive care unit (STICU).

Enrollment: 260 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Intubated and admitted to the Surgical Trauma Intensive Care Unit (STICU)
• Subjects must be eligible to start treatment within 24 hours of their initial intubation

Exclusion criteria

• Patient anticipated to be extubated within 24 hours following STICU admission
• Hypersensitivity to acetylcysteine.
• Pregnancy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Double Blind