Comparison of Different Ventilation Mode During One-lung Ventilation

Fudan University logo

Fudan University

Status

Completed

Conditions

Ventilator-Induced Lung Injury
One Lung Ventilation
Thoracic Surgery

Treatments

Other: PCV mode
Other: VCV mode

Study type

Interventional

Funder types

Other

Identifiers

NCT03061617
B2012-064

Details and patient eligibility

About

It is controversial as to which ventilation mode is better in one-lung ventilation(OLV), volume controlled ventilation(VCV) or pressure controlled ventilation(PCV). This study was designed to figure out if there was any difference between these two modes on oxygenation and postoperative complications under the condition of protective ventilation(PV).

Full description

This is a single center, single blinded prospective study on two different ventilation mode during one lung ventilation for patients under video assistant thoracoscopy(VATS) lobectomy. After institutional approval and written informed consent were obtained, 60 patients with primary lung cancer under VATS lobectomy in Zhongshan Hospital Fudan University were enrolled and randomized into two groups:VCV group(group V) or PCV group(group P). Inclusion criteria were age between 18-75 years , ASA I-II, lateral decubitus position with at least 1h OLV and preoperative FEV1>50% predicted. Preoperative exclusion criteria were previous lobectomy , COPD , asthma, uncompensated cardiac disease or contraindications for epidural catheter. Intraoperative exclusion criteria were SpO2 under 90% after intratracheal suction, reconfirmation the position of double lumen tracheal tube(DLT) and recruitment maneuver of dependant lungs.

Enrollment

64 patients

Sex

All

Ages

18 to 75 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

ASA I-II, lateral decubitus position with at least 1h OLV and preoperative FEV1>50% predicted

Exclusion criteria

Preoperative exclusion criteria were previous lobectomy , COPD , asthma, uncompensated cardiac disease or contraindications for epidural catheter. Intraoperative exclusion criteria were SpO2 under 90% after intratracheal suction, reconfirmation the position of double lumen tracheal tube(DLT) and recruitment maneuver of dependant lungs

Trial design

Primary purpose

Supportive Care

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

64 participants in 2 patient groups

volume controlled ventilation (VCV)
Other group
Description:
VCV mode, tide volume 6ml/kg, f 12-14, set fixed tide volume for each breath
Treatment:
Other: VCV mode
pressure controlled ventilation (PCV)
Experimental group
Description:
PCV mode, pressure is adjusted to achieve tide volume 6ml/kg, f 12-14
Treatment:
Other: PCV mode

Trial contacts and locations

0

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Data sourced from clinicaltrials.gov

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