Comparison Of DIR-MRI And DCE-MRI In Detection Of Prostate Cancer: A Pilot Study (DIRMP)

University Hospitals of North Midlands NHS Trust

Status: Completed

Conditions: Cancer of the Prostate

Treatments: Other: Magnetic Resonance Imaging

Study type: Interventional

Funder types: Other

Identifiers

NCT02939456

1139

Details and patient eligibility

About

This is a pilot study taking place at University Hospitals of North Midlands NHS Trust. Patients referred for MRI for possible prostate cancer will be invited to take part in the study. Following consent, participants will have an additional MRI sequence performed during their routine MRI called Double Inversion Magnetic Resonance Imaging (DIR-MRI).

Participants scan images and prostate biopsy histology report (if applicable) will be reviewed by the research team.

Full description

This is a pilot study taking place at University Hospitals of North Midlands NHS Trust. Patients referred for MRI for possible prostate cancer will be invited to take part in the study. Following consent, participants will have an additional MRI sequence performed during their routine MRI called Double Inversion Magnetic Resonance Imaging (DIR-MRI). Participants scan images and prostate biopsy histology report (if applicable) will be reviewed by the research team. The research team will look at the variability of LNR score amongst the two scan typed and the DCE-MRI and DIR-MRI images will be correlated with biopsy results to give an indication of the accuracy.

Enrollment: 150 patients

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients referred for prostate MRI for possible prostate cancer
• Safe to undergo an MRI scan
• Able to give informed consent

Exclusion criteria

• MRI referrals where prostate cancer is not the question
• Patients who are not safe to undergo an MRI scan
• Patients who have undergone prostate biopsy in the previous 10 weeks
• Patients unable to give informed consent

Trial design

Primary purpose: Diagnostic

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

---

150 participants in 1 patient group

DIR-MRI

Other group

Description:

Participants will have Double Inversion Recovery Magnetic Resonance Imaging (DIR-MRI) as well as the standard Dynamic Contrast Enhanced Magnetic Imaging (DCE-MRI)

Treatment:

Other: Magnetic Resonance Imaging