Comparison of Dressing Materials of Donor Site of Split-thickness Skin Graft; Paraffin Mesh Gauze vs Povidone-Iodine Foam at SMBB Institute of Trauma Karachi

Shaheed Mohtarma Benazir Bhutto Institue of Trauma

Status: Not yet enrolling

Conditions: Skin Graft Wounds

Treatments: Procedure: Paraffin mesh gauze dressing for donor site of Split-thickness skin graft; Procedure: Povidine-iodine foam dressing for donor site of Split-thickness skin graft

Study type: Interventional

Funder types: Other

Identifiers

NCT07257991

IRB000195/SMBBIT/Approval/2025

Details and patient eligibility

About

The goal of this clinical trial is to learn if povidone-iodine foam dressing is better in achieving complete reepithelialization of donor site wounds after harvest of split-thickness skin graft as paraffin mesh gauze.

The main questions it aims to answer are:

Does povidone-iodine foam dressing promotes complete reepithelialization earlier in comparison? Which type of dressing will require fewer replacements? Which type of dressing material is associated with less pain?

Non-probability consecutive sampling method will be used and participants divided in two groups. Donor site wounds after split-thickness skin graft harvest will be dressed using two different dressing materials. Participants will be followed until complete epithelialization with change of dressing on follow-ups if required. Complete epithelialization is usually achieved within two weeks.

Enrollment: 82 estimated patients

Sex: All

Ages: 18 to 75 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Undergoing skin graft with donor site size between 25 to 200 cm2

Exclusion Criteria:'

• Patients wit history of disease impairing wound healing (Diabetes, Malignancy, Cancer, taking immunosuppressants)
• Pregnant or lactating females

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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82 participants in 2 patient groups

PG GROUP

Active Comparator group

Description:

Paraffin gauze dressing will be used.

Treatment:

Procedure: Paraffin mesh gauze dressing for donor site of Split-thickness skin graft

PI GROUP

Experimental group

Description:

Povidone-iodine foam dressing will be used in this group.

Treatment:

Procedure: Povidine-iodine foam dressing for donor site of Split-thickness skin graft