Comparison of Effect on Quality of Recovery Outcome Between Systemic Lidocaine and Dexamethasone in Patients Undergoing Laparoscopic Cholecystectomy

Yonsei University

Status: Terminated

Conditions: Asymptomatic Gallstones Without Cholecystitis; Gallbladder Polyp

Treatments: Drug: Dexamethasone; Drug: Lidocaine

Study type: Interventional

Funder types: Other

Identifiers

NCT02224170

4-2014-0530

Details and patient eligibility

About

The primary purpose of this study is to compare the effect of lidocaine and dexamethasone on postoperative quality of recovery after laparoscopic cholecystectomy

Enrollment: 8 patients

Sex: All

Ages: 20 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ASA I-II patients aged between 20 and 65 year undergoing laparoscopic cholecystectomy due to gallbladder polyp or asymptomatic gallstones without cholecystitis

Exclusion criteria

1. Steroid therapy or immunocompromised patients
2. Diabetes mellitus
3. Allergy to lidocaine or dexamethasone
4. Severe renal dysfunction (serum creatinine more than 1.6mg/dl)
5. Severe liver disease ( liver enzymes more than two times normal values)
6. History of atrioventricular block
7. Have a difficulty in understanding QoR-40 (40-item quality-of-recovery scoring system) or Korean language
8. History of physicologic disease

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

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8 participants in 2 patient groups

Lidocaine group

Experimental group

Treatment:

Drug: Lidocaine

Dexamethasone group

Active Comparator group

Treatment:

Drug: Dexamethasone