Comparison of Effect-site Concentration of Remifentanil for Preventing Cough Against Endotracheal Tube During Anesthetic Emergence According to Anesthetics (Sevoflurane, Desflurane, and Propofol)

Yonsei University

Status: Completed

Conditions: Female Patients Undergoing Thyroidectomy

Treatments: Drug: up-and-down method to find out effective concentration of remifentanil for preventing cough

Study type: Interventional

Funder types: Other

Identifiers

NCT01351285

4-2011-0019

Details and patient eligibility

About

It has been reported that target-controlled infusion of remifentanil can reduce cough against endotracheal tube during emergence from general anesthesia. We hypothesized that effective concentration of remifentanil for preventing cough during anesthetic emergence varies depending on the type of main anesthetic agents which is administered with remifentanil during general anesthesia. The purpose of this study is to evaluate the effective concentrations of remifentanil to prevent coughing during emergence from general anesthesia according to main anesthetic agent (sevoflurane, desflurane, and propofol).

Enrollment: 78 patients

Sex: Female

Ages: 20 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• aged 20-60
• ASA classification I~II
• female patients
• patients who undergoing thyroidectomy

Exclusion criteria

• Patients with acute or chronic respiratory disease
• patient who has smoking history
• patient who has hypertension
• patient who has esophageal reflux
• patient who having an expectorant or cough remedy

Trial design

78 participants in 3 patient groups

Sevo group

Experimental group

Description:

undergoing sevoflurane-remifentanil anesthesia

Treatment:

Drug: up-and-down method to find out effective concentration of remifentanil for preventing cough

Des group

Active Comparator group

Description:

undergoing desflurane-remifentanil anesthesia

Treatment:

Drug: up-and-down method to find out effective concentration of remifentanil for preventing cough

Pro group

Active Comparator group

Description:

undergoing propofol-remifentanil anesthesia

Treatment:

Drug: up-and-down method to find out effective concentration of remifentanil for preventing cough