Comparison of Effectiveness and Costs of Post-diagnosis Treatment in Dementia (AD-Euro)

Radboud University Medical Center

Status

Completed

Conditions

Dementia

Treatments

Other: General Practitioners

Other: Multidisciplinary Memory Clinic

Study type

Interventional

Funder types

Other

Identifiers

NCT00554047

ADE 072510

ZonMw 80-007022-98-07703

ZonMw 945-07-7039

Details and patient eligibility

About

In the Netherlands a rapidly increasing number of multidisciplinary memory clinics (MMC) currently diagnose 25% of the patients with dementia. Following the diagnostic work-up, MMCs are increasingly involved in post-diagnosis treatment and coordination of care, which probably is very important for patients and caregivers, but also very time consuming and expensive. This study will focus on the important question whether this complex post-diagnosis treatment and care coordination, evaluated both on effectiveness and costs, should be carried out by MMCs (intervention) or by General Practitioners (GPs) (control) as pivot of delivery of health care for these patients.

Objectives: To determine MMCs' effectiveness and cost-effectiveness in post-diagnosis treatment and care-coordination for dementia-patients and their caregivers compared to the post-diagnosis treatment and care coordination by GPs.

Time schedule: 12 months for including patients and their caregivers and 12 months of follow-up.

Annex Study: Specifically for the Health Technology Assessment (HTA) methodology study the main study will be extended with some experimental proxy measurements and alternative measurement approaches.

The objective of this Annex-study is to explore the feasibility and validity of Health Related Quality of Life (HRQL) value measurement in dementia patients. And to study the characteristics of proxy rating in HRQL research in dementia and the suitability and validity of yielding HRQL measurements by proxy assessment. Furthermore to explore the validity, reliability, and feasibility of the EQ5D and EQ6D in dementia research (in patients and in/by proxies); response shift, and alternative (more simple) methods of HRQL measurement and validate the Dutch versions of the QOL-AD and the use of the CarerQol-7D in dementia research.

Enrollment

220 estimated patients

Sex

All

Volunteers

No Healthy Volunteers

Inclusion criteria

A patient with a new dementia diagnosis made at the MMC of the participating centre fulfilling DSM-IV-TR criteria with a CDR 0.5, 1 or 2
Each patient has a caregiver
Both patients and caregivers can provide informed consent for participation in the study

Exclusion criteria

Life expectancy less than 1 year
Living in a nursing home
Already evaluated as being suitable for living in a nursing home
Data collection impossible (e.g., due to severe visual/hearing/language impairment, mood disorder, or behavioral disturbances)
The patient's general practitioner does not agree to participate
Already participating in another study
The patient visits the MMC for a second opinion
Travel distance between MMC and patient's living address more than 50 kilometers
A definite indication for memory clinic follow up:
- A definite need for symptomatic drug treatment as judged by treating physician (e.g., Dementia with Lewy Bodies)
- A definite need for specialist guidance as judged by treating physician (e.g., Creutzfeldt-Jakob Disease, severe Frontotemporal Lobar Disease)
- A definite wish for symptomatic drug treatment by patient or caregiver
- A definite need for guidance from psychiatric services involved in the memory clinic