Comparison of Effectiveness Between the Combination of Lidocaine Sprayed at Laryngeal Inlet and on the Cuff of Endotracheal Tube Versus Intravenous Lidocaine for Reducing Cough During Extubation

Khon Kaen University

Status: Completed

Conditions: Reducing Cough During Extubation

Treatments: Drug: 2% lidocaine intravenous; Drug: 10% lidocaine sprayed

Study type: Interventional

Funder types: Other

Identifiers

NCT04090112

HE611394

Details and patient eligibility

About

Coughing during extubation of endotracheal tube (ETT) is a common problem that leads to poor surgical results including hemodynamic change, rebleeding at the surgical wound and wound dehiscence. Recently, lidocaine has been introduced for reducing coughing during extubation. However, data comparing routes of lidocaine application are lacking, thus, this study compared the combination of lidocaine sprayed on laryngeal inlet and cuff of ETT versus intravenous lidocaine injection for efficacy in reducing coughing

Full description

A prospective randomized control trial was conduct with 164 patients. They were randomly allocated into Gr. A and B. Group A received four puffs of 10% lidocaine sprayed at the cuff of ETT and four puffs at laryngeal inlet whereas Gr. B received 15 mg/kg of 2% lidocaine intravenous injection prior to extubation. The same general anesthesia protocol was applied in all of the patients. Incidence and severity of cough during extubation was evaluated. Furthermore, incidence of 24-hour postoperative adverse events (including sore throat, dysphagia, and hoarseness) and hemodynamic response after extubation were analyzed.

Enrollment: 164 patients

Sex: All

Ages: 19 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients who underwent elective surgery with American Society of Anesthesiologists physical status classifications of I and III

Exclusion criteria

• patients having body mass index more than 35 kg/m2, high risk of aspiration, chronic smokers more than ten pack-years, chronic cough or recent upper respiratory infection, suspected difficult airway, retained ETT prior surgery, surgery at oral cavity, neck and thoracic region, operative time more than 120 minutes or less than 30 minutes, and history of lidocaine allergy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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164 participants in 2 patient groups

the study group (Group A)

Experimental group

Description:

Patients received four puffs of 10% lidocaine sprayed at the cuff of ETT and four puffs at laryngeal inlet

Treatment:

Drug: 10% lidocaine sprayed

Comparator group (Group B)

Active Comparator group

Description:

Patients received 15 mg/kg of 2% lidocaine intravenous injection prior to extubation

Treatment:

Drug: 2% lidocaine intravenous