Comparison of Effectiveness of Zinc Supplementation With ORS and Bacillus Clausii Versus Zinc With ORS and Saccharomyces Boulardii in Acute Watery Diarrhea in Paediatric Patients

RESnTEC, Institute of Research

Status: Completed

Conditions: Acute Watery Diarrhea

Treatments: Drug: Saccharomyces boulardii; Drug: Bacillus clausii; Drug: Zinc; Drug: ORS

Study type: Interventional

Funder types: Other

Identifiers

NCT06540209

AWD-CHLAHORE

Details and patient eligibility

About

The current study was carried out to directly compare the effectiveness of zinc supplementation with ORS and Bacillus clausii versus zinc with ORS and Saccharomyces boulardii among the local pediatric population presenting with acute watery diarrhea.

Full description

The results and importance of effective treatment for acute watery diarrhea in pediatric patients vary throughout the world. Previously, very limited literature was available comparing the efficacy of Bacillus clausii and Saccharomyces boulardii in acute watery diarrhea, providing mixed results. The current study aims to directly compare the effectiveness of zinc supplementation with ORS and Bacillus clausii versus zinc with ORS and Saccharomyces boulardii.

Enrollment: 60 patients

Sex: All

Ages: 3 months to 5 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients of either gender
• Aged 3 months to 5 years
• With acute watery diarrhea last less fewer than 14 days
• Presenting with mild to moderate dehydration

Exclusion criteria

• Patients with a history of blood or pus in their stools
• History of recent antibiotic or probiotic treatment
• Patients with immunodeficiency conditions, acute systemic illnesses, or chronic diarrhea
• Patients with hypersensitivity to Bacillus clausii or Saccharomyces boulardii

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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60 participants in 2 patient groups

Bacillus clausii + zinc+ ORS group

Experimental group

Description:

Patients received zinc supplementation with ORS and Bacillus clausii

Treatment:

Drug: ORS

Drug: Zinc

Drug: Bacillus clausii

Saccharomyces boulardii +zinc+ ORS group

Experimental group

Description:

Patients were given zinc with ORS and Saccharomyces boulardii

Treatment:

Drug: ORS

Drug: Zinc

Drug: Saccharomyces boulardii