Comparison of Effects of Intravenous Midazolam and Ketamine on Emergence Agitation

Inje University

Status: Completed

Conditions: Psychomotor Agitation

Treatments: Drug: Midazolam; Drug: Ketamine

Study type: Interventional

Funder types: Other

Identifiers

NCT02256358

2012-127

Details and patient eligibility

About

Compare the effects of intravenous midazolam and ketamine on emergence agitation after sevoflurane anesthesia

Full description

Emergence agitation is self-limiting aggressive behavior that develops in the early period of awakening from anesthesia. A high level of preoperative anxiety is a risk factor for emergence agitation using Aono's four-point scale. Midazolam and ketamine was administered to the patients to decrease of preoperative anxiety. We aimed to compare the emergence agitation between midazolam group and ketamine group.

Enrollment: 68 patients

Sex: All

Ages: 2 to 6 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American society of anesthesiologists physical status 1-2 aged 2-6 years old, who were scheduled to undergo ophthalmic surgery (<2hr)

Exclusion criteria

• children with central nervous system disorders,history of allergy to the study drugs (midazolam and ketamine), history of recent respiratory tract infection

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

---

68 participants in 2 patient groups

Midazolam

Active Comparator group

Description:

Intravenous 0.1 mg/kg midazolam was administered to the patients as premedication drug before entering operating room.

Treatment:

Drug: Midazolam

Ketamine

Experimental group

Description:

Intravenous 1 mg/kg ketamine was administered to the patients as premedication drug before entering operating room.

Treatment:

Drug: Ketamine