Comparison of Effects of Oxycodone and Sufentanil on Cardiovascular Stress Induced by Tracheal Intubation in the Patients With Coronary Heart Disease Undergoing Major Noncardiac Surgery

China Medical University

Status: Completed

Conditions: Cardiovascular

Treatments: Drug: Oxycodone 10mg; Drug: Sufentanil

Study type: Interventional

Funder types: Other

Identifiers

NCT04121416

Oxycodone VS Sufentanil

Details and patient eligibility

About

To evaluate the effect of oxycodone and sufentanil in preventing cardiovascular responses to tracheal intubation in the patients with coronary heart disease (CHD).

Full description

Laryngoscopy and tracheal intubation can provoke an increase of blood pressure (BP) and/or HR [1.2]. This hemodynamic stress may lead to an imbalance between myocardial oxygen consumption and supply and therefore induce myocardial ischemia, which may be endurable in the patients with normal cardiovascular condition but is potential harmful to the patients with coronary heart disease. Thus it is critical to attenuate the cardiovascular stress induced by laryngoscopy and endotracheal intubation in the high risk patients.

Enrollment: 50 patients

Sex: Female

Ages: 60 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

The coronary angiography from each patient showed that lesions exist in at least one main coronary artery

Exclusion criteria

a history of reactive airway disease, gastroesophageal reflux, morbid obesity, a known or predicted difficult airway

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Quadruple Blind

---

50 participants in 2 patient groups

Oxycodone group

Experimental group

Treatment:

Drug: Oxycodone 10mg

Sufentanil group

Experimental group

Treatment:

Drug: Sufentanil