Comparison of Effects of Scalp Block and Intravenous Esmolol on Hemodynamic Response Following the Skull Pins Application for Elective Supratentorial Craniotomy

Khon Kaen University

Status: Completed

Conditions: Hemodynamic Instability

Treatments: Procedure: Scalp block; Drug: Esmolol

Study type: Interventional

Funder types: Other

Identifiers

NCT06268275

HE651314

Details and patient eligibility

About

The goal of this clinical trial is to compare hemodynamic response (MAP, SBP, DBP and HR) between scalp block and intravenous esmolol while skull pins application in patients undergoing elective supratentorial craniotomy under general anesthesia.

Enrollment: 90 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age 18-65 years old
• BMI 18-30 kg/m2
• American Society of Anesthesiologists (ASA) status I-III
• Elective supratentorial craniotomy under general anesthesia
• Required application of skull pins

Exclusion criteria

• Poor controlled hypertensive condition (Baseline BP ≥ 160/110 mmHg)
• Thrombocytopenia / Coagulopathy
• Preoperative atrioventricular block (More than 2nd degree AV block)
• Emergency surgery
• Posterior fossa / Intracranial aneurysm surgery
• Pregnancy
• Chronic use of pain control
• Contraindication to beta-blockers
• Allergy to the drugs used in the study

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

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90 participants in 2 patient groups

Group S

Experimental group

Description:

Receive 30 ml of 0.25% bupivacaine with 1% lidocaine (1:1) with adrenaline 1:200,000 infiltration for 10 minutes before skull pins application.

Treatment:

Procedure: Scalp block

Group E

Active Comparator group

Description:

Receive intravenous esmolol 1 mg/kg bolus over 1 minute before skull pins application.

Treatment:

Drug: Esmolol