Comparison of Efficacy in Removal of Advanced Glycation End Products (AGEs) Between Super High-flux Hemodialysis and Postdilution Online Hemodiafiltration: A Single-center, Prospective, Open-label, Crossover Randomized Controlled Trial

Mahidol University

Status: Active, not recruiting

Conditions: End Stage Renal Disease

Treatments: Device: postdilution online hemodiafiltration; Device: super high-flux hemodialysis

Study type: Interventional

Funder types: Other

Identifiers

NCT05777148

3619

Details and patient eligibility

About

The goal of this clinical trial is to compare efficacy in advanced glycation end products removal between Super high-flux Hemodialysis and high-volume post-dilution online hemodiafiltration. The main question it aims to answer are

• Efficacy : endothelial dysfunction biomarker (AGEs) in super high-flux hemodialysis compared to online HDF
• Safety profile : Dialysate albumin loss, Intradialytic complication

Participants will be asked to randomized in 2 groups : Super high-flux HD or post dilution ol-HDF Researchers will compare SHF-HD and ol-HDF to see whether SHF-HD could remove AGEs better than ol-HDF

Enrollment: 22 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Chronic HD > 3 months
• Adequate small molecule uremic toxins removal
• Kt/v > 1.8 in HD 2 times/week
• Kt/v > 1.2 in HD 3 times/week
• BFR > 300 mL/min
• RKF < 100 ml/day
• Hemodynamically stable for > 2 weeks

Exclusion criteria

• contraindicated to anticoagulant
• active malignancy
• advanced liver disease

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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22 participants in 2 patient groups

postdilution online hemodiafiltration

Experimental group

Description:

hemodialysis by using post dilution online HDF technique

Treatment:

Device: postdilution online hemodiafiltration

super high-flux hemodialysis

Experimental group

Description:

hemodialysis by using super high-flux dialyzer

Treatment:

Device: super high-flux hemodialysis