Comparison of Efficacy of Azithromycin Alone vs Combination of Azithromycin and Probiotics in Management of Mild to Moderate Acne Vulgaris

Hayatabad Medical Complex

Status and phase: Active, not recruiting; Phase 4

Conditions: Acne Vulgaris II or III Degree

Treatments: Drug: Azithromycin 250 MG Oral Capsule; Drug: Azithromycin 250 MG Oral Capsule Along with Oral Probiotics

Study type: Interventional

Funder types: Other

Identifiers

NCT07384793

HMC Peshawar

Details and patient eligibility

About

The Goal of this Clinical trial is to compare the efficacy of oral azithromycin alone with combination therapy of oral azithromycin and probiotics to see is there any significant difference in outcome of two treatment modalities in mild to moderate acne vulgaris

Enrollment: 60 estimated patients

Sex: All

Ages: 15 to 35 years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria: Participants with mild to moderate acne on basis of global acne assessment scale score of 2 or 3 and with 20 to 50 total lesion count will be included.

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Exclusion Criteria:

History of active localized or generalized infection History of autoimmune disease History of other facial skin diseases/ excessive facial hair or scars History of using isotretinoin or oral contraceptive pills in past 6 months History of already using antibiotics for acne treatment History of facial cosmetic procedures within last 3 months History of allergy to drugs used in study History of using drugs that may interact with azithromycin Currently pregnant or lactating women

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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60 participants in 2 patient groups

Oral Azithromycin group

Active Comparator group

Description:

The participants in this arm of study will receive only Oral Azithromycin to treat their Acne

Treatment:

Drug: Azithromycin 250 MG Oral Capsule

Oral Azithromycin and Oral probiotic combination

Active Comparator group

Description:

The participants in this arm of study will receive both Oral Azithromycin and Oral Probiotics to treat their Acne

Treatment:

Drug: Azithromycin 250 MG Oral Capsule Along with Oral Probiotics