Comparison of Efficacy of Azithromycin and Levamisole Versus of Azithromycin in in the Treatment of Acne

Ahvaz Jundishapur University of Medical Sciences

Status and phase

Completed

Phase 3

Phase 2

Conditions

Acne

Treatments

Drug: Levamisole

Study type

Interventional

Funder types

Other

Identifiers

NCT01348321

126/د (Other Identifier)

Acne and levamisole

Details and patient eligibility

About

Different immunologic mechanisms contribute to development of inflammation in acne vulgaris and immunologic effect of levamisole has been demonstrated.

Objective: The aim of this study was to compare azithromycin and levamisole with azithromycin alone in the treatment of acne vulgaris.

Full description

An investigator blind clinical randomized prospective two months study was designed. One hundred sixty nine acne patients presenting in our outpatients clinic were randomly allocated to two treatment groups: azithromycin and levamisole ( group 1 ) and azithromycin alone ( group 2 ) .One hundred forty eight patients completed the duration of the study and their clinical responses were evaluated and compared by using monthly photographic records .

Enrollment

169 patients

Sex

All

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Patients who had at least 20 papules and/or pustules,
Patients with nodule and/or cyst disregarding the number of papules of pustules, were included the study. There was not any age limit

Exclusion criteria

were using any type of systemic treatment for their acne at the time of visit or during the last month;
had any hematological, renal or hepatic disease
were pregnant or lactating;
had drug-induced acne;
were using alcohol, anti-convulsants or anti-coagulants.