Comparison Of Efficacy Of Hydrocortisone And Methyl Prednisolone In Acute Severe Asthma

University of Karachi

Status: Invitation-only

Conditions: Asthma Acute

Treatments: Drug: Methylprednisolone,

Study type: Observational

Funder types: Other

Identifiers

NCT06171932

Zia ud din university karachi

Details and patient eligibility

About

COMPARISON OF EFFICACY OF HYDROCORTISONE AND METHYLPREDNISOLONE IN ACUTE SEVERE ASTHMA

In this study Investigator will compare the efficacy of hydrocortisone and methyl prednisolone in acute severe asthma that will lead to final result and beneficial effects that will help in early resoloution of symptoms and help in preventing recurrence

Full description

investigator will compare the efficacy of hydrocortisone v/s methylprednisolone in management of patients presented with acute severe asthma in emergency.

A local study was conducted in 2009, after that there is a big research gap exists at national level although international literature is available on the same but it can not be generalized to our population due to socio, geographic and economic differences so there is dire need to conduct this study this gives a strong rationale to implement in our settings

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Either Gender (18 to 50 years old)
• Patient presenting to emergency department with acute severe asthma

Exclusion criteria

• Patients with critical illness or pregnant females. .Patient treated other than hydrocortisone and methylprednisolone. .Patients not willing to participate in study.
• Life threatening asthma
• Near fatal asthm

Trial design

60 participants in 2 patient groups

HYDROCORTISONE

Description:

Group A will comprise of 30 patients will be treated with 200 mg hydrocortisone followed by 3 doses of hydrocortisone 100 mg 6 hours apart for next 24hrs

METHYLPREDNISOLONE

Description:

Group B will be treated with methylprednisolone 125 mg stat

Treatment:

Drug: Methylprednisolone,