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Comparison of Efficacy of Ivabradine Versus Metoprolol (IMAGE)

C

Col. Suthee Panichkul

Status and phase

Unknown
Phase 4

Conditions

Coronary Artery Disease

Treatments

Drug: Ivabradine and Metoprolol

Study type

Interventional

Funder types

Other

Identifiers

NCT01755663
Pharmongkutklao

Details and patient eligibility

About

Ivabradine may be better than Metoprolol for controlling heart rate before Coronary CTA.

Enrollment

60 estimated patients

Sex

All

Ages

18 to 80 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • elective patient on scheduled for 640 slices CT coronary at Phramonkutklao hospital
  • Resting heart rate > 70 BPM
  • age > 18 years and informed consent

Exclusion criteria

  • Heart rate > 100 BPM
  • BP <100/60 mmHg
  • recent congestive heart failure in 1 mo.
  • SA node, AV node disease and AF
  • on permanent pacemaker
  • CrCL < 15ml/min. , AST or ALT > 3x UNL
  • on HR reducing drug such as diltiazem, verapamil, digitalis
  • contraindication for ivabradine or metoprolol

Trial design

Primary purpose

Diagnostic

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Double Blind

60 participants in 2 patient groups

Ivabradine
Experimental group
Description:
Patients will recieved ivabradine(5) 1 tab bid pc for 3 day and the day of CT, and recieve placebo of metoprolol
Treatment:
Drug: Ivabradine and Metoprolol
metoprolol
Active Comparator group
Description:
Metoprolol (100) 1/2 tab bid pc for 3 day and the day of CT coronary , and placebo of ivabradine
Treatment:
Drug: Ivabradine and Metoprolol

Trial contacts and locations

1

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Central trial contact

Purich Surunchupakorn, M.D.

Data sourced from clinicaltrials.gov

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