Comparison of Efficacy of Ivabradine Versus Metoprolol (IMAGE)

Col. Suthee Panichkul

Status and phase: Unknown; Phase 4

Conditions: Coronary Artery Disease

Treatments: Drug: Ivabradine and Metoprolol

Study type: Interventional

Funder types: Other

Identifiers

NCT01755663

Pharmongkutklao

Details and patient eligibility

About

Ivabradine may be better than Metoprolol for controlling heart rate before Coronary CTA.

Enrollment: 60 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• elective patient on scheduled for 640 slices CT coronary at Phramonkutklao hospital
• Resting heart rate > 70 BPM
• age > 18 years and informed consent

Exclusion criteria

• Heart rate > 100 BPM
• BP <100/60 mmHg
• recent congestive heart failure in 1 mo.
• SA node, AV node disease and AF
• on permanent pacemaker
• CrCL < 15ml/min. , AST or ALT > 3x UNL
• on HR reducing drug such as diltiazem, verapamil, digitalis
• contraindication for ivabradine or metoprolol

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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60 participants in 2 patient groups

Ivabradine

Experimental group

Description:

Patients will recieved ivabradine(5) 1 tab bid pc for 3 day and the day of CT, and recieve placebo of metoprolol

Treatment:

Drug: Ivabradine and Metoprolol

metoprolol

Active Comparator group

Description:

Metoprolol (100) 1/2 tab bid pc for 3 day and the day of CT coronary , and placebo of ivabradine

Treatment:

Drug: Ivabradine and Metoprolol