Comparison of Efficacy of Oral Fluconazole Versus Oral Itraconazole in the Treatment of Pityriasis Versicolor

Khyber Teaching Hospital

Status and phase: Enrolling; Phase 4

Conditions: Pityriasis Versicolor

Treatments: Drug: Fluconazole; Drug: Itraconazole

Study type: Interventional

Funder types: Other

Identifiers

NCT06922344

84/DME/KMC

Details and patient eligibility

About

This study compares the efficacy of two drugs, namely flucanazole and itraconazole for the treatment of a common fungal infection of skin.

Full description

Pityriasis versicolor is a common fungal infection of the superficial skin layers. Avalible treatment options include topical and systemic drugs. fluconazole and itraconazole are commonly used systemic agents. The aim of this study is to compare the efficacy of the two systemic drugs.

Enrollment: 106 estimated patients

Sex: All

Ages: 18 to 50 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All cases of Pityriasis versicolor

Exclusion criteria

• Patients with history of chronic renal or liver disease, malignancy , or undergoing any kind of chemotherapy or radiotherapy or having cardiac conduction abnormalities.
• Patients who received any anti-fungal therapy in the last one month.
• Pregnant or lactating women.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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106 participants in 2 patient groups

Group A, Fluconazole group

Experimental group

Description:

Group A consists of patients in whom oral fluconazole is given in dose of 300mg once weekly for 2 weeks.

Treatment:

Drug: Fluconazole

Group B, Itraconazole group

Experimental group

Description:

Group B consists of patients in whom oral Itraconazole is given in dose of 100mg Twice for 5 days.

Treatment:

Drug: Itraconazole