Comparison of Emergence Agitation Between Sevoflurane and Desflurane Anesthesia After Orthognathic Surgery

Chung-Ang University Hosptial, Chung-Ang University College of Medicine

Status and phase: Completed; Phase 4

Conditions: Emergence Agitation

Treatments: Drug: Sevoflurane; Drug: Desflurane

Study type: Interventional

Funder types: Other

Identifiers

NCT01878656

Chung-Ang University Hospital

Details and patient eligibility

About

Emergence agitation is a major concern in patients undergoing orthognathic surgery. The patients may experience the sense of suffocation during emergence due to nasotracheal intubation and orofacial edema. Postoperative pain is also associated with emergence agitation. Although there is a lot of studies about emergence agitation in children, there is a few in adults, furthermore, no data about comparison of emergence agitation between sevoflurane and desflurane anesthesia in adults. Therefore, the investigators would like to compare the incidence and severity of emergence agitation between sevoflurane and desflurane anesthesia in adults after orthognathic surgery.

Enrollment: 144 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiologists(ASA) physical status classification 1 or 2 patients
• patients scheduled for orthognathic surgery

Exclusion criteria

• severe cardiopulmonary disease
• psychological disease
• patients who cannot understand Korean

Trial design

Primary purpose: Health Services Research

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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144 participants in 2 patient groups

Sevoflurane

Active Comparator group

Description:

administration of sevoflurane with oxygen and nitrous oxide as same ratio of 3 L/min for maintenance of general anesthesia

Treatment:

Drug: Sevoflurane

Desflurane

Active Comparator group

Description:

administration of desflurane with oxygen and nitrous oxide as same ratio of 3 L/min for maintenance of general anesthesia

Treatment:

Drug: Desflurane