Comparison of Emergence and Oxygenation During One-lung Ventilation With Desflurane and Propofol Anesthesia

Juntendo University

Status: Active, not recruiting

Conditions: Lung Cancer

Treatments: Drug: desflurane; Drug: propofol

Study type: Interventional

Funder types: Other; Industry

Identifiers

NCT02324283

12-97

Details and patient eligibility

About

Which is more adequate general anesthetic agent, desflurane or propofol, for emergence and recovery time, and perioperative oxygenation in lung resection surgery?

Full description

The investigators plan to investigate the effects of desflurane on oxygenation (prevention of HPV) of OLV compare with propofol which is used in general anesthesia for lung resection.

Transesophageal echocardiography (TEE) wiill be used to measure pulmonary blood flow during surgery visible and successively. To confirm the effect of HPV by measuring the change in pulmonary blood flow. The correlation between the blood oxygen concentration and attenuation of blood flow will be investigated.

Enrollment: 80 patients

Sex: All

Ages: 20 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients agree to participate in the study
• Patients undergoing lung cancer surgery requiring one-lung ventilation.
• American Society of Anesthesiologists Physical Status Class 1 or 2

Exclusion criteria

• Patients with any of the following will be excluded from lung cancer patients.
• New York Heart Association Classification more than 2
• Respiratory dysfunction Vital Capacity or percent predicted Forced expiratory volume in one second is less than 50 %
• Pulmonary hypertension with mean pulmonary arterial pressure more than 30 mmHg
• Coagulation dysfunction
• The administration of steroids and immunosuppressive agents within 3 months prior to surgery
• Infection with active inflammation
• Pneumonectomy patients
• Cases of epidural anesthesia is contraindicated

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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80 participants in 2 patient groups

Desflurane

Active Comparator group

Description:

Desflurane group: this group of patients receives desflurane as the main anesthetic agent in addition to remifentanil infusion at 0.1\~0.3 mcg/kg/min during one-lung anesthesia. Bispectral index will be maintained between 45 and 50. Arterial blood gases and pulmonary blood flow by using tansesphageal echocardiogrphy will be measured.

Treatment:

Drug: desflurane

Propofol

Active Comparator group

Description:

Propofol group: this group of patients receives propofol as the main anesthetic agent in addition to remifentanil infusion at the rate of 0.1\~0.3 mcg./g/min during one-lung anesthesia. Bispectral index will be maintained between 45 and 50. Arterial blood gases and pulmonary blood flow by using tansesphageal echocardiogrphy will be measured.

Treatment:

Drug: propofol