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Comparison of EMR-P With Conventional EMR

Zhejiang University logo

Zhejiang University

Status

Unknown

Conditions

Colonic Polyp

Treatments

Procedure: CEMR
Procedure: EMR-P

Study type

Interventional

Funder types

Other

Identifiers

Details and patient eligibility

About

Colorectal cancer is the third most common cancer in men and the second most common cancer in women.There are about 14 million cases of colonoscopy in the United States every year. In recent years, the incidence of colorectal cancer in China has risen sharply, becoming a serious threat to people's health.For small(≤ 9mm) lesions, endoscopic biopsy forceps and cold snare polypectomy can be used to remove.For larger lesions, especially laterally spreading tumor,endoscopic mucosal resection is a classic method of treatment.With the increasing diameter of the lesion size(> 20mm),we also need to adopt endoscopic piecemeal mucosal resection or endoscopic submucosal dissection.

As IT, Hook knife, BB, and other devices appear constantly, foreign researchers recently adopted a variation of conventional EMR(CEMR), namely endoscopic mucosal resection with circumferential precutting(EMR - P).The technology is superior to conventional EMR for 10 to 20 mm polyps.Moreover, preliminary studies suggest that it has good safety and efficacy, and may be a better method for treatment of 10-20mm polyps under colonoscopy.

This clinical trial is being conducted to compare the efficacy and safety of two methods of polypectomy, CEMR and EMR-P, for 10-20mm colorectal polyps.

Enrollment

220 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • One polyp or lesion of 10-20mm at the most proximal of colorectal
  • Adult patients (≥18 years old)
  • Polyps other than pedicled polyps

Exclusion criteria

  • There was submucosal infiltration under endoscope
  • Residual lesions after endoscopic resection
  • Inflammatory bowel disease, familial polyps, electrolyte abnormalities, coagulation disorders, or severe organ failure
  • Pregnant or nursing
  • No informed consent has been signed
  • Patients taking NSAIDs or other anticoagulants
  • sedated colonoscopy

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

220 participants in 2 patient groups

group P
Experimental group
Treatment:
Procedure: EMR-P
group C
Other group
Treatment:
Procedure: CEMR

Trial contacts and locations

7

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Central trial contact

Chaohui Yu, PhD

Data sourced from clinicaltrials.gov

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