Comparison of Etomidate Plus Propofol, Etomidate Alone on Induction of Anesthesia

University of California (UC) Davis logo

University of California (UC) Davis

Status and phase

Completed
Phase 4

Conditions

Surgery

Treatments

Drug: Propofol 1 mg/kg
Drug: Etomidate 0.3 mg/kg
Drug: Propofol 2mg/kg
Drug: Etomidate 0.15 mg/kg

Study type

Interventional

Funder types

Other

Identifiers

NCT03820388
909765

Details and patient eligibility

About

Comparison of Etomidate plus Propofol vs. Propofol or Etomidate alone during induction of anesthesia.

Full description

Comparison of Etomidate plus Propofol vs. Propofol or Etomidate alone during induction of anesthesia. The specific aims are testing patient reactions during induction, and in the post-anesthesia care unit (PACU).

Enrollment

75 patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • Patients scheduled for elective non-cardiac surgery
  • ASA physical status of 2 or 3
  • Age equal to or greater than 18 years old

Exclusion criteria

  • Adults unable to provide consent
  • Age less than 18 years old
  • Pregnant women
  • Prisoners
  • Difficult airway
  • Morbid Obesity
  • Preoperative sedation use
  • Severe Cardiac, pulmonary and liver disease
  • Hypotension and shock
  • Emergency surgeries
  • Allergy to propofol or etomidate

Trial design

Primary purpose

Supportive Care

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Single Blind

75 participants in 3 patient groups

Propofol Group
Experimental group
Description:
Propofol 2 mg/kg
Treatment:
Drug: Propofol 2mg/kg
Etomidate Group
Experimental group
Description:
Etomidate 0.3 mg/kg
Treatment:
Drug: Etomidate 0.3 mg/kg
Propofol plus Etomidate Group
Experimental group
Description:
Propofol 1 mg/kg plus Etomidate 0.15 mg/kg
Treatment:
Drug: Etomidate 0.15 mg/kg
Drug: Propofol 1 mg/kg

Trial documents
3

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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