Comparison of Etomidate Plus Propofol, Etomidate Alone on Induction of Anesthesia

University of California (UC) Davis

Status and phase: Completed; Phase 4

Conditions: Surgery

Treatments: Drug: Propofol 1 mg/kg; Drug: Etomidate 0.3 mg/kg; Drug: Propofol 2mg/kg; Drug: Etomidate 0.15 mg/kg

Study type: Interventional

Funder types: Other

Identifiers

NCT03820388

909765

Details and patient eligibility

About

Comparison of Etomidate plus Propofol vs. Propofol or Etomidate alone during induction of anesthesia.

Full description

Comparison of Etomidate plus Propofol vs. Propofol or Etomidate alone during induction of anesthesia. The specific aims are testing patient reactions during induction, and in the post-anesthesia care unit (PACU).

Enrollment: 75 patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Patients scheduled for elective non-cardiac surgery
• ASA physical status of 2 or 3
• Age equal to or greater than 18 years old

Exclusion criteria

• Adults unable to provide consent
• Age less than 18 years old
• Pregnant women
• Prisoners
• Difficult airway
• Morbid Obesity
• Preoperative sedation use
• Severe Cardiac, pulmonary and liver disease
• Hypotension and shock
• Emergency surgeries
• Allergy to propofol or etomidate

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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75 participants in 3 patient groups

Propofol Group

Experimental group

Description:

Propofol 2 mg/kg

Treatment:

Drug: Propofol 2mg/kg

Etomidate Group

Experimental group

Description:

Etomidate 0.3 mg/kg

Treatment:

Drug: Etomidate 0.3 mg/kg

Propofol plus Etomidate Group

Experimental group

Description:

Propofol 1 mg/kg plus Etomidate 0.15 mg/kg

Treatment:

Drug: Etomidate 0.15 mg/kg

Drug: Propofol 1 mg/kg