Comparison of Etomidate, Propofol and Etomidate-propofol Combination in Terms of Effects on Haemodynamic Response to Intubation

T.C. ORDU ÜNİVERSİTESİ

Status and phase: Completed; Phase 4

Conditions: Induction of Anaesthesia

Treatments: Drug: propofol; Drug: etomidate-propofol; Drug: etomidate

Study type: Interventional

Funder types: Other

Identifiers

NCT02186990

Odu-2

Details and patient eligibility

About

The purpose of this study is to evaluate the effect of propofol, etomidate and propofol-etomidate combination on hemodynamic responses during laryngoscopy and tracheal intubation and assess the adverse effect related to this drugs.

Enrollment: 90 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• between 18 - 65 age
• ASA I - II status
• elective surgery

Exclusion criteria

• emergency surgery
• pregnancy
• alcohol and drug abuse
• HT and cardiovascular disease
• BMI > 25 kg/m2
• hypersensitivity against study drug
• sedative drug use in last month
• difficult intubation

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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90 participants in 3 patient groups

propofol

Active Comparator group

Treatment:

Drug: etomidate-propofol

etomidate

Active Comparator group

Treatment:

Drug: etomidate

propofol-etomidate

Active Comparator group

Treatment:

Drug: propofol