Comparison of Expression of Carcinogenesis-related Molecular Markers in the Patients With Colon Cancer and Polyp

Seoul National University

Status

Active, not recruiting

Conditions

Colorectal Adenoma

Colorectal Cancer

Study type

Observational

Funder types

Other

Identifiers

NCT05638542

B-1305-203-009

Details and patient eligibility

About

A study of carcinogenesis-related molecular markers in the patients with colorectal cancer and colorectal adenoma.

Full description

The chromosomal instability (CIN) pathway, the CpG island methylator phenotype (CIMP) pathway and the microsatellite instability (MSI) pathway are three major carcinogenesis pathways to colorectal cancer (CRC). In this study, the investigators aimed to investigate distinctive molecular features of carcinogenesis pathways among healthy control, colorectal adenoma, and CRC and compare their molecular progression according to patients' sex and tumor location as well as disease stage.

Enrollment

582 patients

Sex

All

Ages

18+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Control group: subjects with no evidence of colorectal adenoma or colorectal cancer
Colorectal adenoma group: Patients with colorectal adenomas greater than or equal to 10 mm in diameter according to the endoscopic presentation as well as histological validation of colorectal adenoma.
Colorectal cancer group: Patients whose biopsy specimen is histologically confirmed as colorectal adenocarcinoma

Exclusion criteria

Subjects age under 18 years
Previous history of colorectal neoplasms
Patients with high bleeding risk or patients who must maintain anti-coagulant or anti-platelet agents
Denial to participate in this study