Comparison of Extra Vascular Lung Water Index in Covid-19 ARDS and "Typical"ARDS Patients

Istanbul University - Cerrahpasa (IUC)

Status: Withdrawn

Conditions: Ventilation Perfusion Mismatch; Respiratory Distress Syndrome, Adult; Covid19; Pulmonary Edema

Treatments: Device: Pulmonary Vascular Permeability Index; Device: Extravascular Lung Water Index

Study type: Observational

Funder types: Other

Identifiers

NCT04508933

0308202247

Details and patient eligibility

About

Covid-19 also primarily affects endothelium that line up the alveoli. The resulting hypoxemia may differ from "typical" Acute Respiratory Distress Syndrome (ARDS) due to maldistribution of perfusion related to the ventilation. Thus, pathophysiology of Covid-19 ARDS is different, which requires different interventions than typical ARDS. The investigators will assess whether extravascular lung water index and permeability of the alveolar capillary differs from typical ARDS with transpulmonary thermodilution (TPTD) technique. Extravascular Lung Water Index (EVLWI) and Pulmonary Vascular Permeability Index (PVPI) will be compared.

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• ARDS defined by Berlin Criteria longer than 24 hours
• Undergoing mechanical ventilation
• Noradrenaline demand >0.1 mcg/kg/min

Exclusion criteria

• Not meeting ARDS criteria
• Noninvasive mechanical ventilation
• ARDS resolved shorter than 24 hours
• Shock resolved

Trial design

0 participants in 2 patient groups

Typical ARDS

Description:

ARDS due to non Covid19 causes

Treatment:

Device: Extravascular Lung Water Index

Device: Pulmonary Vascular Permeability Index

C-ARDS

Description:

ARDS due to Covid19

Treatment:

Device: Extravascular Lung Water Index

Device: Pulmonary Vascular Permeability Index