Comparison of Factor XII Levels in Gestational Diabetic and Healthy Pregnancies

Acibadem University

Status: Completed

Conditions: Complement System; Disorder; Diabetic Pregnancy; Pregnancy Related

Treatments: Diagnostic Test: Diabetic pregnancy; Diagnostic Test: Non-diabetic pregnancy

Study type: Observational

Funder types: Other

Identifiers

NCT03583216

ATADEK-2017/10

Details and patient eligibility

About

To compare Factor XII levels in gestational diabetic and healthy pregnancies.

Full description

Thirty singleton term pregnant women with a diagnosis of Type I, Type II or gestational diabetes and thirty singleton uncomplicated term healthy pregnant women will be included in our study. Our study will be performed at Istanbul Acibadem Maslak Hospital, Turkey. Blood will be drawn from each patient when they are hospitalized and before they deliver either vaginally or by cesarean section. Blood will be drawn into two citrate tubes, each will contain 4 ml blood. Blood will be transferred to the lab immediately and will be centrifuged. The supernatant will be stored at -80°C. When the anticipated number of samples are completed Factor XII levels will be calculated in each sample.

Enrollment: 60 patients

Sex: Female

Ages: 18 to 50 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Term pregnancy
• Pregnant patients with a diagnosis of Type I diabetes
• Pregnant patients with a diagnosis of Type II diabetes
• Pregnant patients with a diagnosis of Gestational diabetes
• Non-diabetic pregnancies
• Uncomplicated pregnancies

Exclusion criteria

• Preterm pregnancy
• Postterm pregnancy
• Pregnant patients with a diagnosis of systemic diseases other than diabetes
• Complicated pregnancies

Trial design

60 participants in 2 patient groups

Diabetic pregnancy

Description:

Pregnant patients with a diagnosis of Type I, Type II or gestational diabetes will be included in this arm. Blood will be drawn from each patient when they are hospitalized and before they deliver either vaginally or by cesarean section. Blood will be drawn into two citrate tubes, each will contain 4 ml blood.

Treatment:

Diagnostic Test: Diabetic pregnancy

Non-diabetic pregnancy

Description:

Healthy non-diabetic pregnant patients will be included in this arm. Blood will be drawn from each patient when they are hospitalized and before they deliver either vaginally or by cesarean section. Blood will be drawn into two citrate tubes, each will contain 4 ml blood.

Treatment:

Diagnostic Test: Non-diabetic pregnancy